A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)

Awouafack, Maurice D.; Wong, Chin Piow; Tane, Pierre; Morita, Hiroyuki

doi:10.1016/j.phytol.2018.06.024

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…was isolated from the same extract (Ateba et al, 2016a). Vitexin (4) and robusflavone C (5) were extracted from an ethanol fraction of twigs of E. robustum (Awouafack et al, 2018).…”

Section: Flavonoidsmentioning

confidence: 99%

“…The flavonol kaempferol (10) was isolated from roots of E. chinense (Thongnest et al, 2013) and twigs of E. robustum (Awouafack et al, 2018).…”

Section: Flavonoidsmentioning

confidence: 99%

“…respectively, were also identified for the first time in the genus. Among flavanones, prunin (42) was isolated from the twigs of E. robustum (Awouafack et al, 2018).…”

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

“…The isoflavones, genistein (43), 2ʹ-hydroxygenistein (44), genistin (54), genistein-8-C-glucoside (55), 2ʹ-hydroxygenistein-7-O-glucoside (61), eriosemaone D ( 62) and the new compound 63) were identified and/or isolated from E. laurentii (Ateba et al, 2013;2014b;2016a;2016b). Compound 43 was also obtained from the EtOAc-soluble portion of an EtOH extract of the twigs of E. robustum (Awouafack et al, 2018). 5,7,4′-trihdroxy-2′methoxyisoflavone (45), 4′,5-dihydroxy-2′,7- dimethoxyisoflavone (46) and 4′,7″-bisgenistein (53) were obtained from a dichloromethane/methanol (1:1 v/v) root extract of E. psoraleoides (Wanyama, 2010).…”

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

“…5,7,4′-trihdroxy-2′methoxyisoflavone (45), 4′,5-dihydroxy-2′,7- dimethoxyisoflavone (46) and 4′,7″-bisgenistein (53) were obtained from a dichloromethane/methanol (1:1 v/v) root extract of E. psoraleoides (Wanyama, 2010). The coumaronochromone named eriocoumaronochromone (72) was isolated for the first time from an EtOH extract of the twigs of E. robustum, along with desmoxyphyllin A (74) (Awouafack et al, 2018). Lupinalbin A (73) was proven in methanol extracts of the aerial and underground parts of E. laurentii (Ateba et al, 2014b;2016b) and in a dichloromethane/methanol (1:1 v/v) root extract of E. psoraleoides (Wanyama, 2010).…”

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

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The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?

2021

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The genus Eriosema (Fabaceae) includes approximately 150 species widely distributed across tropical and subtropical regions of the world (Africa, Neotropics, Asia and Australia). Throughout these regions, several species are used since centuries in different traditional medicinal systems, while others are used as food or food supplement. The present review attempts to critically summarize current information concerning the uses, phytochemistry and pharmacology of the Eriosema genus and to evaluate the therapeutic potential. The information published in English and French (up to September 2020) on ethnopharmacology or traditional uses, chemistry, pharmacology and toxicology of Eriosema genus was collected from electronic databases [SciFinder, PubMed, Google, Google Scholar, Scopus, Web of Science, Prelude Medicinal Plants—http://www.ethnopharmacologia.org/recherche-dans-prelude/?plant, The Plant List (http://www.theplantlist.org/), POWO (http://powo.science.kew.org/) and IUCN Red List Categories (https://www.iucnredlist.org/)], conference proceedings, books, M.Sc. and Ph.D. dissertations. The information retrieved on the ethnomedicinal indications of Eriosema genus allowed to list 25 species (∼16.6% of the genus). The majority of uses is recorded from Africa. Phytochemical analyses of 8 species led to the identification and/or isolation of 107 compounds, with flavonoids (69.2%), chromones (7.5%) and benzoic acid derivatives (3.7%) as the main chemical classes. Pharmacological investigations with crude extracts and isolated compounds showed a broad range of activities including aphrodisiac, estrogenic, anti-osteoporosis, hypolipidemic, anti-diabetic, anti-diarrheal, anti-microbial, anti-oxidant, anthelmintic, anti-cancer, and acetylcholinesterase inhibitory activities. Despite the low number of Eriosema species tested, there is convincing evidence in vitro and in vivo studies validating some traditional and ethnobotanical uses. However, the utility of several of the described uses has not yet been confirmed in pharmacological studies. Reviewed data could serve as a reference tool and preliminary information for advanced research on Eriosema species.

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“…was isolated from the same extract (Ateba et al, 2016a). Vitexin (4) and robusflavone C (5) were extracted from an ethanol fraction of twigs of E. robustum (Awouafack et al, 2018).…”

Section: Flavonoidsmentioning

confidence: 99%

“…The flavonol kaempferol (10) was isolated from roots of E. chinense (Thongnest et al, 2013) and twigs of E. robustum (Awouafack et al, 2018).…”

Section: Flavonoidsmentioning

confidence: 99%

“…respectively, were also identified for the first time in the genus. Among flavanones, prunin (42) was isolated from the twigs of E. robustum (Awouafack et al, 2018).…”

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

Section: Chemical Classes N°compoundsmentioning

confidence: 99%

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The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?

2021

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Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Matchide,

Hnin,

Nguekeu

et al. 2023

Chemistry & Biodiversity

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A new fructofuranoside glycerol, dryoptkirbioside (1), along with fourteen known compounds (2‐15), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HRESI‐MS) and chemical conversions. The n‐hexane‐soluble portion and the EAFA fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC50 values ranging from 4.0 to 8.8 µg/mL). Aspidinol P (5) and aspidinol B (6) exhibited moderate to low cytotoxicity on the three cell lines (IC50 values ranging from 20.4 to 58.7 µM). The MeOH extract and n‐hexane‐soluble portion had excellent activities against Staphylococcus aureus and Bacillus subtilis (MICs 11.7 and 23.4 µg/mL), whereas the EtOAc‐ and n‐BuOH‐soluble portions were significantly active on S. aureus (MICs 46.9 and 93.8 µg/mL). The main fractions EAFB, EAFC and nBFB displayed excellent activity against S. aureus (MICs 11.7 and 23.4 µg/mL). Aspidinol B (6) had significant activity, while aspidinol P (5) was moderately active against S. aureus and B. subtilis (MICs 42.0 and 89.5 µM).

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Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Hook R.M.Tryon (Cyatheaceae) rhizomes

Tsepeupon Matchide,

Sonfack Fozeng,

Tchuente Tchuenmogne

et al. 2024

Biochemical Systematics and Ecology

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A new coumaronochromone and a new alkanoyl-dihydrofuranoflavone glycoside from Eriosema robustum (Fabaceae)

Cited by 7 publications

References 25 publications

The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?

The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?

Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes

Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Hook R.M.Tryon (Cyatheaceae) rhizomes

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