A New Cytotoxic Pregnanone from Calotropis gigantea

Zhunian, Wang; Wang, Maoyuan; Mei, Wen‐Li; Han, Zhuang; Dai, Hao‐Fu

doi:10.3390/molecules13123033

Cited by 72 publications

(59 citation statements)

References 13 publications

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“…From the roots of C. gigantea, coroglaucigenin, gofruside and frugoside showed cytotoxicity against K562 and SGC-7901 cancer cells [24,34]. IC 50 values were 4.7 and 14 µg/mL for both coroglaucigenin and gofruside, and 3.4 and 6.5 µg/mL for frugoside.…”

Section: Calotropis Giganteamentioning

confidence: 95%

“…Calotroposides from the root bark of C. gigantea have also been reported to possess cytotoxic activity against cancer cell lines [22]. Calotropone from the roots of C. gigantea was cytotoxic towards K562 cells with IC 50 value of 9.2 µg/mL [24]. From the root bark of C. procera, calotroposides K, M and S displayed the strong cytotoxic activity against A549, U373 and PC-3 cancer cells with IC 50 values ranging from 0.5-4.4, 0.5-4.5 and 0.1-0.2 μM, respectively [38,39].…”

Section: Cytotoxicity Of Other Compoundsmentioning

confidence: 99%

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Cytotoxic Cardenolides from Calotropis Species: A Short Review

Chan¹,

Sweidan²,

Wong³

et al. 2017

Rec.Nat.Prod.

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Abstract:From different plant parts of Calotropis species (C. gigantea and C. procera), various classes of compounds such as oxypregnanes, terpenoids, sterols, cardenolides and flavonoids have been isolated. Of these compounds, the cardenolides stand out as many of them have anticancer properties. Cardenolides are C 23 steroids with a five-membered unsaturated butyrolactone ring consisting of a steroid nucleus, a lactone moiety at C-17 and a sugar moiety at C-3. The roles of cardenolides in the treatment of human cancer have been established as they can induce apoptosis and inhibit the growth of cancer cells. Structure-activity relationship analyses have yielded some interesting findings on their cytotoxicity. Compounds with six-membered ring sugar groups generally have significantly stronger inhibitory activity than those with five-membered ring sugar groups. A formyl or methyl-hydroxyl group at C-10 enhances cytotoxicity while the presence of a 4´-OH or 16-OH group decreases cytotoxicity. Chemical modification of 2"-oxovoruscharin, a novel cardenolide extracted from the root bark of C. procera, has led to the synthesis of UNBS1450. The compound is characterized by more potent antiproliferative activity, lower toxicity, and is a strong sodium pump inhibitor and inducer of non-apoptotic cell death. UNBS1450 is currently in Phase I clinical trials.

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Section: Calotropis Giganteamentioning

confidence: 95%

Section: Cytotoxicity Of Other Compoundsmentioning

confidence: 99%

Cytotoxic Cardenolides from Calotropis Species: A Short Review

Chan¹,

Sweidan²,

Wong³

et al. 2017

Rec.Nat.Prod.

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“…Calotropis procera and C. gigantea are two most common species of this genus. The therapeutic potential of Calotropis procera (Watt and Breyer-Brandwisk 1962, Kartikar and Basu 1994, Arya and Kumar 2005, Sehgal et al 2006, Choedon et al 2006 and Calotropis gigantea (Chitime et al 2005, Wang et al 2008, Saratha et al 2009, Kumar et al 2010) is very well documented. The two species are reported to contain various phyto-constituents (Akindele et al 2017, Chandrawat and Sharma 2015, Shetty et al 2015, Verma 2014, Meena et al 2012, Agarwal et al 2011 in all plant parts but little work has been done on phytochemical screening of the calli of Calotropis procera and C. gigantea.…”

Section: Introductionmentioning

confidence: 92%

Comparison of Extraction Efficiency of Aqueous and Methanolic Extracts from Plant Tissues and Callus Cultures of Calotropis procera and Calotropis gigantea

Rani

Singh

Sood

2017

Plant Tissue Cult. & Biotech.

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Extracts of plants may contain bioactive substances which could be used as natural antimicrobial agents against many microbes. Callus from the leaf material of Calotropis procera and C. gigantea was raised on different hormonal combinations and different extracts i.e. 50% methanolic, 90% methanolic and aqueous extracts of leaf and callus were prepared. The extraction efficiency of different extracts of plant tissue and callus was calculated and compared. Callus tissue is advantageous over plant tissues for extraction of phyto-constituents for the basic reason that purification and isolation of active constituents are easier and also scale up strategies can be applied in vitro. Moisture content of tissue and the callus were analyzed and improved extraction efficiency was calculated after subtracting the moisture content.

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“…Pembuktian secara ilmiah tentang aktivitas antikanker dari tanaman ini telah dilaporkan diantaranya Senyawa calotropon dari bagian akar mempunyai aktivitas sitotoksik terhadap Leukemia K562 dan gastric cancer 7901 (Wang et al, 2008). Ekstrak metanol dan fraksi kloroform dari bagian bunga mempunyai aktivitas antitumor pada mencit ascites carcinoma (Habib, Aziz and Karim, 2010).…”

Section: Pendahuluanunclassified