A new deep eutectic solvent-agarose gel with hydroxylated fullerene as electrical “switch” system for drug release

Guo, Yingying; Wang, Yan; Chen, Hangping; Jiang, Wanhang; Zhu, Chanrong; Toufouki, Sara; Yao, Shun

doi:10.1016/j.carbpol.2022.119939

Cited by 15 publications

(7 citation statements)

References 43 publications

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“…87 Therefore, the development of ES-controlled portable drug carriers is important to promote wound healing and skin care. Guo et al 88 developed a composite conductive gel system based on TEGs-C 60 and DES (Fig. 10a).…”

Section: As Solventsmentioning

confidence: 99%

Deep eutectic solvents as an emerging green platform for the synthesis of functional materials

Ma,

Yang,

et al. 2024

Green Chem.

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Section: As Solventsmentioning

confidence: 99%

Deep eutectic solvents as an emerging green platform for the synthesis of functional materials

Ma,

Yang,

et al. 2024

Green Chem.

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“…Currently, materials with excellent biocompatibility mainly come from natural sources, including plants and animals. Examples of such materials include chitosan [120], alginates [121], cellulose [122], agarose [123], as well as synthetic polymers and inorganic substances (bioceramics [124], titanium alloys [125]). Utilizing natural materials has several advantages.…”

Section: Biocompatibilitymentioning

confidence: 99%

Recent Advances of Conductive Hydrogels for Flexible Electronics

Wang,

Yang,

Jiang

et al. 2024

Preprint

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Conductive hydrogels combine the properties of both hydrogels and electrical conductivity, making them soft, flexible, and biocompatible. These properties enable them to conform to irregular surfaces, stretch and bend without losing their electrical conductivity, and interface with biological systems. Conductive hydrogels can be utilized as conductive traces, electrodes, or as a matrix for flexible electronics. Exciting applications in sensors, tissue engineering and human-machine interaction have been demonstrated worldwide. This review comprehensively covers the progress in this field, focusing on several main aspects: functional materials, performance improvement strategies, and wearable applications in human-related areas. Furthermore, the major approaches and challenges for improving their mechanical properties, conductivity, and long-term stability are systematically summarized.

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“…To overcome the limitations of conventional therapeutics and increase the relevance and sensitivity of the drug delivery process, materials that respond to a range of endogenous (pH, enzyme expression, and redox potential) or exogenous (temperature, ultrasound, magnetic fields, and light) stimuli can be used as substrates for drug delivery systems [ 124 ]. Agarose hydrogel is electrically conductive, pH-responsive, and thermally reversible, making it an ideal tunable drug delivery system for loading and controlling the release of drugs by stimulating a sensitive response under different environmental conditions, increasing the retention time of the drug, and thus, reducing the dose frequency and toxic effects of the drug [ 125 ]. Endogenous drug delivery directly transfers a carrier-bound drug to a target site.…”

Section: Biomedical Applications Of Agarose and Its Derivativesmentioning

confidence: 99%

Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review

Jiang

Chen

et al. 2023

Marine Drugs

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Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical properties, and high biological activity. Natural agarose hydrogel has a single structural composition that prevents it from adapting to complex biological environments. Therefore, agarose can be developed into different forms through physical, biological, and chemical modifications, enabling it to perform optimally in different environments. Agarose biomaterials are being increasingly used for isolation, purification, drug delivery, and tissue engineering, but most are still far from clinical approval. This review classifies and discusses the preparation, modification, and biomedical applications of agarose, focusing on its applications in isolation and purification, wound dressings, drug delivery, tissue engineering, and 3D printing. In addition, it attempts to address the opportunities and challenges associated with the future development of agarose-based biomaterials in the biomedical field. It should help to rationalize the selection of the most suitable functionalized agarose hydrogels for specific applications in the biomedical industry.

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A new deep eutectic solvent-agarose gel with hydroxylated fullerene as electrical “switch” system for drug release

Cited by 15 publications

References 43 publications

Deep eutectic solvents as an emerging green platform for the synthesis of functional materials

Deep eutectic solvents as an emerging green platform for the synthesis of functional materials

Recent Advances of Conductive Hydrogels for Flexible Electronics

Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review

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