By constructing an ecological complex of Chinese medicine specialty industries, it can help farmers to increase their income and prosperity and promote rural revitalization. This study takes the spatio-temporal subjects of 30 provinces, cities and autonomous regions (excluding Hong Kong, Macao, Taiwan and Tibet) from 2011-2021 as the research objects. Firstly, a coupled and coordinated evaluation index system of Chinese medicine industry and rural revitalization is established and a comprehensive evaluation model based on entropy value method is used to explore the development level of both; secondly, based on the index system and development level, a density-based spatial clustering method with noise is used to divide the 30 provinces into regions; finally, the coordination relationship between the two is explored in the regional division as well as in the spatio-temporal perspective with the help of coupled coordination degree model. At the same time, this paper also analyzes the obstacle factors in the process of coupling and coordination between TCM development and rural revitalization by using the obstacle degree model, and puts forward reasonable suggestions for TCM development in each region to help rural revitalization. In terms of spatial dimension, the level of coupling and coordination between TCM development and rural revitalization is characterized by the spatial distribution of "high in coastal areas and low inland areas"; in terms of regional division, the level of coupling and coordination between TCM development and rural revitalization is characterized by In terms of regional division, the level of coupling and coordination between the two is characterized by the regional distribution of "low level of development and low level of coordination, high level of development and high level of coordination"; in terms of obstacle factors, industrial prosperity is the key obstacle factor affecting the coupling and coordination of TCM development and rural revitalization.