A New Dibenzocyclooctadiene Lignan from Stems of Schisandra lancifolia and its Bioactivities

Li, Yin-Ke; Wu, Xian‐Xue; Li, Ming; Du, Gang; Hu, Qiu‐Fen

doi:10.14233/ajchem.2014.15706

Cited by 3 publications

(2 citation statements)

References 10 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Sichuan, China) and tested for HIV-1 inhibitory effects in a microtiter syncytium formation infectivity assay. Among them, both 162 and 165 displayed anti-HIV-1 activity with EC 50 values of 4.5 lM and TI values of 6.7 (Li et al 2012b(Li et al , 2009aLei et al 2007).…”

Section: Aryltetralin-type Lignansmentioning

confidence: 99%

Plant-derived lignans as potential antiviral agents: a systematic review

Wang

et al. 2021

Phytochem Rev

View full text Add to dashboard Cite

Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have even been developed as therapeutic drugs. In this review, 630 lignans, including those obtained from medicinal plants and their chemical derivatives, were systematically reviewed for their antiviral activity and mechanism of action. The compounds discussed herein were published in articles between 1998 and 2020. The articles were identified using both database searches (e.g., Web of Science, Pub Med and Scifinder) using key words such as: antiviral activity, antiviral effects, lignans, HBV, HCV, HIV, HPV, HSV, JEV, SARS-CoV, RSV and influenza A virus, and directed searches of scholarly publisher’s websites including ACS, Elsevier, Springer, Thieme, and Wiley. The compounds were classified on their structural characteristics as 1) arylnaphthalene lignans, 2) aryltetralin lignans, 3) dibenzylbutyrolactone lignans, 4) dibenzylbutane lignans, 5) tetrahydrofuranoid and tetrahydrofurofuranoid lignans, 6) benzofuran lignans, 7) neolignans, 8) dibenzocyclooctadiene lignans and homolignans, and 9) norlignans and other lignoids. Details on isolation and antiviral activities of the most active compounds within each class of lignan are discussed in detail, as are studies of synthetic lignans that provide structure–activity relationship information.

show abstract

Section: Aryltetralin-type Lignansmentioning

confidence: 99%

Plant-derived lignans as potential antiviral agents: a systematic review

Wang

et al. 2021

Phytochem Rev

View full text Add to dashboard Cite

show abstract

“…Wuweizi, the fruits of genus Schisandra (Schisandraceae), have been widely used in traditional Chinese medicine (TCM) as tonic, sedative, and astringent agents for a long time [1]. Modern phytochemical and pharmacological studies have shown that this family is a rich source of lignans and lanostane-and cycloartane-type triterpenoids, which possess various beneficial pharmacological effects such as antihepatitis, antitumor, and anti-HIV-1 activities [2][3][4][5][6]. Wuweizi can reduce the levels of stress in ratsʼ CORT and Glu, and protect the structure of the adrenal cortex [7].…”

mentioning

confidence: 99%

Lanostane Triterpenoids from the Stems ofSchisandra glaucescens

Zou

Yang²,

Jiang³

et al. 2012

Planta Med

View full text Add to dashboard Cite

Ten new triterpenoids, schiglausins A-J (1-10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.

show abstract