2012
DOI: 10.1002/ps.3441
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A new dibenzoylhydrazine with insecticidal activity against Anopheles mosquito larvae

Abstract: As a result of the similar toxicity exhibited by the experimental compound KU-106 to that shown by commercial products, the present study demonstrated that the use of DBH compounds to combat harmful dipteran insects, such as mosquitoes, remains unexplored and invites further systematic toxicity tests using other derivatives of the DBH class of compounds.

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Cited by 21 publications
(12 citation statements)
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“…The control targets of non‐steroidal agonists are mainly Lepidoptera pests, but not insects from other orders . Meanwhile, several pests have developed resistance or cross‐resistance to some non‐steroidal agonist compounds with weak inner attraction activities to insects and low insecticidal efficacies, for example, compounds with a single diacylhydrazine structure of the skeleton . To solve this problem, identification of new compounds with novel structures or higher activity is imperative.…”
Section: Discussionmentioning
confidence: 99%
“…The control targets of non‐steroidal agonists are mainly Lepidoptera pests, but not insects from other orders . Meanwhile, several pests have developed resistance or cross‐resistance to some non‐steroidal agonist compounds with weak inner attraction activities to insects and low insecticidal efficacies, for example, compounds with a single diacylhydrazine structure of the skeleton . To solve this problem, identification of new compounds with novel structures or higher activity is imperative.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, dibenzoylhydrazine compounds can be applied successfully as environmentally safe insecticides against lepidopteran and coleopteran insect species (Dhadialla et al, 1998;Pineda et al, 2004;Dhadialla et al, 2005;Dhadialla & Ross, 2007;Smagghe et al, 2012;Dallaire & Cusson, 2017). However, their potential to control mosquito larvae is largely unknown (Morou et al, 2013). These products act via binding to the ecdysone receptor causing precocious lethal molting (Tohidi-Esfahani et al, 2011;Sundaravadivelan et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…To this end, synthetic 20E non-steroidal agonists such as dibenzoylhydrazines (DBHs), which mimic the action of 20E by competitively binding to the ecdysteroid receptor, resulting in high ecdysteroid activity [21, 22], could be utilized. When provided to larvae of some Lepidopteran and Dipteran species, DBHs induce precocious and incomplete molting, ultimately leading to death [2125]. These compounds have extremely low toxicity to mammals and are non-carcinogenic [26, 27], and although reduced fitness of adult stages following DBH exposure has been documented in agricultural lepidopteran species [24], their potential use against adult stages of malaria vectors has not been tested.…”
Section: Introductionmentioning
confidence: 99%