A New Dichlorocarbenoid Equivalent for Cyclopropanation and Olefination

Chien, Ching‐Ting; Tsai, Chia-Chung; Tsai, Chi-Hui; Chang, Tsin‐Yuan; Tsai, Ping-Kuei; Wang, Y.-C.; Yan, T.-H.

doi:10.1055/s-2006-942004

Cited by 1 publication

(2 citation statements)

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“…In addition to treatment, these factors also play an important role in TME for cancer and infection. Considering their role as biomarkers, cytokines (IL-6, 10, 17, 27, 35; TNF-; IFN-; and TGF-) and chemokines (CCL-2, 5, 18; CCR-4; CXCR -4 ; CX3CL) -1; and CXCL-1, 5, 8, 13) are frequently targeted for the treatment of lung cancer [26]. Among other stromal cell types in theTME, macrophages are the major secretors of the cytokine IL-6.…”

Section: The Role Of Cytokines In Immunotherapy and Cancermentioning

confidence: 99%

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Cytokine Profile in Lung Cancer Patients: Anti-tumor and Oncogenic Cytokines

Freddy Elad,

Angelina V.,

Owoicho

et al. 2023

Preprint

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Lung cancer accounts for the majority of cancer cases. In recent years, checkpoint inhibitor immunotherapy (ICI) has emerged as a new treatment. A better understanding of the tumor microenvironment, or TMJ, or the immune system surrounding the tumor is needed. Cytokines are small proteins that carry messages between cells and are known to play an important role in the body's response to inflammation and infection. Cytokines are important for immunity in lung cancer. It promotes tumor growth (oncogenic cytokines) or inhibits tumor growth (anti-tumor cytokines) by controlling signaling pathways for growth, proliferation, metastasis, and apoptosis. The immune system relies heavily on cytokines. They can also be produced in the laboratory for therapeutic use. Cytokine therapy helps the immune system stop the growth or kill cancer cells. Interleukins and interferons are two types of cytokines used to treat cancer. This article begins by addressing the role of the tumor microenvironment (TMJ) and its components in lung cancer. This review also highlights the functions of various cytokines such as IL, TGF and TNF.

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Section: The Role Of Cytokines In Immunotherapy and Cancermentioning

confidence: 99%

“…A recent study using in vivo mouse and in vitro human lung tumor models demonstrated that the mechanism by which IL-6 stimulates CCL-2/5 causes EMT and resistance in different stages of lung cancer [26]. Blocking IL-6 modifies TME, complicating the as yet undiagnosed model of carcinogenesis.…”

Section: The Role Of Cytokines In Immunotherapy and Cancermentioning

confidence: 99%