A new dihydrofuranocoumarin from<i>Opopanax hispidus</i>(Friv.) Griseb.

Ghasemi, Sabrieh; Habibi, Zohreh

doi:10.1080/14786419.2014.947487

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…(Apiaceae) [ 21 ], while peucedanin ( 6 ) and officinalin ( 2 ) were isolated from the chloroform extract of the aerial parts of Opopanax hispidus (Friv.) Griseb [ 22 ]. Moreover peucedanin ( 6 ) was purified from the petroleum ether-diethyl ether extract of P. officinale L. fruits [ 20 ] and the diethyl ether, methyl- tert -butyl ether, and ethyl acetate extracts of P. morisonii Bess.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Antimicrobial Activity of Coumarin Derivatives from Fruits of Peucedanum luxurians Tamamsch

et al. 2018

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As a continuation of searching for phytoconstituents that act as promising agents for antimicrobial therapy, rare coumarins were isolated from fruits of Peucedanum luxurians and tested. In a first step, the content of major compounds in the aerial parts and fruits of P. luxurians were compared. The results clearly showed that the fruits with dichloromethane as a solvent yielded, in most cases, higher concentrations of almost all the analyzed coumarins than the aerial parts, with peucedanin detected as the most abundant compound with a concentration of 4563.94 ± 3.35 mg/100 g. Under this perspective, the dichloromethane extract from the fruits of P. luxurians was further submitted to high performance countercurrent chromatography with a mixture of n-hexane, ethyl acetate, methanol, and water 6:5:6:5 (v/v). Combination of HPCCC and prep-HPLC yielded 6′,7′-dihydroxybergamottin (1), officinalin (2), stenocarpin isobutyrate (3), officinalin isobutyrate (4), 8-methoxypeucedanin (5), and peucedanin (6). Isolated compounds were tested against several Gram-positive and Gram-negative bacteria strains. 6′,7′-Dihydroxybergamottin, peucedanin, and officinalin isobutyrate appeared to be the most active against all tested bacteria strains with minimum inhibitory concentration (MIC) values between 1.20 and 4.80 mg/mL. To the best of our knowledge, this is the first report about countercurrent isolation of mentioned coumarins, as well as the first information about their antimicrobial activity.

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Section: Resultsmentioning

confidence: 99%

Isolation and Antimicrobial Activity of Coumarin Derivatives from Fruits of Peucedanum luxurians Tamamsch

et al. 2018

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“…The chloroform extract of the O. hispidus aerial parts afforded coumarins such as 4'-acetyl-3'-senecioyl-3'hydroxymarmesin ( 22), 4'-acetyl-3'-isobutyryloxymarmesin (23) 4 , (+)-3'-hydroxyprantschimgin (24), 39 smirniorin (19), 40 peucedanin (8), officinalin (25) 41 and oreoselon (26) (Figure 2). 4,8,42 In addition to coumarins, flavonoids were also found in O. hispidus, based on qualitative analysis (121.18 mg Res/g extract). 28 To the best of our knowledge, there is no individual flavonoid, isolated and identified from this species.…”

Section: Traditional Usagementioning

confidence: 99%

“…5,6 It is one of the most prominent plant families in the world, representing many genera and a rich source of pharmacologically active secondary metabolites, with high economic and medicinal values. [5][6][7][8] The famous members of this family are Anethum graveolens (dill), Anthriscus cerefolium (chervil), Angelica spp. (angelica), Apium graveolence (celery), Carum carvi (caraway), Coriandrum sativum (coriander), Cuminum cyminum (cumin), Foeniculum vulgare (fennel), Ferula gummosa (galbanum) and Pimpinella anisum (anise), well-known vegetables and/or spices.…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Traditional Uses and Pharmacological Properties of the Genus Opopanax W. D. J. Koch: A Mini-Review

et al. 2020

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The genus Opopanax W.D.J. Koch is a member of the Apiaceae family, distributed throughout the Mediterranean region and comprises only three recognized and well-defined species, O. chironium (L.) W.D.J. Koch, O. hispidus (Friv.) Griseb. and O. persicus Boiss. The species of this genus with yellow flowers are well-known in traditional medicine and consumed as food. This review critically appraises published literature on the phytochemistry, traditional usages, and pharmacological activities of the genus Opopanax. In addition, it provides evidence to suggest that the plants from this genus have potential phytotherapeutic applications. Previous phytochemical and bioactivity studies revealed that the genus Opopanax predominantly produces coumarins, diterpenes, phenolics, and phthalides, and possesses various biological and pharmacological properties, including anticancer, antioxidant and antimicrobial activities. The phytochemical profile and pharmacological activities of the genus Opopanax could be useful for further study and might find additional medicinal applications in evidence-based phytotherapy

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“…The relation between the two parts could not be unambiguously established by the HMBC for there is an oxygen atom between H-8' and C-7. [11] However, according to the molecular formula inferred by HR-ESI-MS and the chemical shift values of C-7 (δ C 143.0) and C-8' (δ C 87.6), both of them are linked to oxygen, and there is only one remaining oxygen atom with undetermined position, it can be determined that the C-7 position and C-8' are linked by an oxygen atom. With the combining of the small coupling constants (J 7',8' = 1.2) of H-7' and H-8' and the small difference between the chemical shifts of two hydrogen on H 2 -9, it can be determined that the relative configuration of the structure is an erythro structure.…”

Section: Introductionmentioning

confidence: 99%

Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity

Bai

Zhang

et al. 2022

Chemistry & Biodiversity

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Nine coumarins including a pair of new enantiomers (1a/1b) and seven known compounds (2 -8) were isolated from Sarcandra glabra (Thunb.) Nakai. Among them, compounds 1a and 1b were naturally occurring coumarin-phenylpropanoid conjugate enantiomers. Their structures were identified by NMR and ECD calculations. Compounds 1-8 were tested for acetylcholinesterase (AchE) inhibiting activity. The results of the enzymology experiment showed that compound 3 demonstrated obvious AchE inhibitory activity which showed the IC 50 value of 1.982 � 0.003 μM, and the binding sites were predicted by molecular docking.

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A new dihydrofuranocoumarin fromOpopanax hispidus(Friv.) Griseb.

Cited by 9 publications

References 25 publications

Isolation and Antimicrobial Activity of Coumarin Derivatives from Fruits of Peucedanum luxurians Tamamsch

Isolation and Antimicrobial Activity of Coumarin Derivatives from Fruits of Peucedanum luxurians Tamamsch

Phytochemistry, Traditional Uses and Pharmacological Properties of the Genus Opopanax W. D. J. Koch: A Mini-Review

Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity

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