A new DNA computing model for the NAND gate based on induced hairpin formation

Liu, Wenbin; Shi, Xiaobo; Zhang, Shemin; Liu, Xiangrong; Xu, Jin

doi:10.1016/j.biosystems.2004.04.005

Cited by 16 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In combination with other platforms and technologies, MBs are now used for protein assays, [21,22] enzyme monitoring, [16][17][18] mRNA tracing in living cells, [12,14,99] biosensors, [19,20,80,82] and molecular computing. [119,122] MB aptamers, [123][124][125][126][127] for example, are protein probes that combine the advantages of the signal-transduction mechanism of MBs and the specificity of molecular recognition by aptamers. [128,129,136,137] They can be used for the highly sensitive and selective detection of proteins and cells.…”

Section: Molecular Beaconsmentioning

confidence: 99%

Molecular Engineering of DNA: Molecular Beacons

et al. 2009

View full text Add to dashboard Cite

Molecular beacons (MBs) are specifically designed DNA hairpin structures that are widely used as fluorescent probes. Applications of MBs range from genetic screening, biosensor development, biochip construction, and the detection of single-nucleotide polymorphisms to mRNA monitoring in living cells. The inherent signal-transduction mechanism of MBs enables the analysis of target oligonucleotides without the separation of unbound probes. The MB stem-loop structure holds the fluorescence-donor and fluorescence-acceptor moieties in close proximity to one another, which results in resonant energy transfer. A spontaneous conformation change occurs upon hybridization to separate the two moieties and restore the fluorescence of the donor. Recent research has focused on the improvement of probe composition, intracellular gene quantitation, protein-DNA interaction studies, and protein recognition.

show abstract

Section: Molecular Beaconsmentioning

confidence: 99%

Molecular Engineering of DNA: Molecular Beacons

et al. 2009

View full text Add to dashboard Cite

show abstract

“…[147] Die ursprünglichen Einsatzfelder der MBs (als PCR-Reportergruppen und in der Allelanalyse) sind in den letzten Jahren enorm erweitert worden. In Kombination mit anderen Systemen und Techniken werden MBs inzwischen in Anwendungen wie Proteinassays, [21,22] Enzymmessungen, [16][17][18] mRNA-Monitoring in lebenden Zellen, [12,14,99] Biosensoren [19,20,80,82] und molekulares Computing [119,122] eingesetzt. MB-Aptamere (MBAs) [123][124][125][126][127] sind ein neuer Typ von Proteinsonden, die die Vorteile des MB-eigenen Signalübertragungsmechanismus mit der Spezifität der molekularen Erkennung von Aptameren verbinden.…”

Section: Ausblickunclassified

Molekulartechnische DNA‐Modifizierung: Molecular Beacons

et al. 2009

View full text Add to dashboard Cite

Molecular Beacons (MBs) sind spezifisch entworfene DNA‐Haarnadelstrukturen, die als Fluoreszenzsonden für verschiedenste Zwecke eingesetzt werden. Die Anwendungen reichen von genetischem Screening über die Herstellung von Biochips und den Nachweis von Einzelnucleotidpolymorphien bis hin zum mRNA‐Monitoring in lebenden Zellen und der Untersuchung von Protein‐Protein‐Wechselwirkungen. Ermöglicht wird dieses breite Anwendungsspektrum durch die besondere Art, mit der MBs mit DNA‐, RNA‐ und Proteinmolekülen wechselwirken. Durch die Haarnadelstruktur der MBs wird eine enge Nachbarschaft zwischen einem Fluoreszenzdonor und einem ‐akzeptor hergestellt, wodurch es zu einem resonanten Energietransfer kommt. Die Hybridisierung der Schleifenregion mit der Zielsequenz bewirkt eine Konformationsänderung der Sonden, die den Donor und Akzeptor auseinanderbewegt und die Fluoreszenz wieder herstellt. Die aktuelle Forschung zielt auf die Verbesserung der Sonden, die intrazelluläre Quantifizierung von Genen und die Anwendung in Studien von Protein‐Protein‐Wechselwirkungen.

show abstract

“…They pointed out that genetic manipulation in molecular sequences can cause different evolutionary results. The same DNA sequence exists hot spots and cold spots in different locations; the mutation probability of the base in the cold spots is far less than the base in hot spots [14,15]. NIU and GU have used DNA evolutionary algorithm to solve flow shop scheduling problems [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Multi-objective Flexible Scheduling Optimization Scheme base on Improved DNA Genetic Algorithm

Nie¹,

Zhong²

2012

JCP

View full text Add to dashboard Cite

In this paper, established a mathematical model for multi-objective flexible scheduling problems, combined Pareto non-dominated sorting method, put forward a hybrid genetic algorithm based on improved DNA computation. To ensure the diversity of the optimal solution sets, designed RNA quaternary encoder mode and genetic operator based on improved DNA computation, adopted sub-area crossover and dynamic mutation, imposed on manipulation of the molecular level. Through simulation, tested the performance of the designed algorithm, compared it with the standard genetic algorithm test results. Simulation results showed the proposed algorithm can provide an optimum searching, owned better seeking abilities; the obtained scheduling results were fairly reasonable. This algorithm can effectively solve the multiobjective flexible scheduling optimization problems.

show abstract

A new DNA computing model for the NAND gate based on induced hairpin formation

Cited by 16 publications

References 8 publications

Molecular Engineering of DNA: Molecular Beacons

Molecular Engineering of DNA: Molecular Beacons

Molekulartechnische DNA‐Modifizierung: Molecular Beacons

Multi-objective Flexible Scheduling Optimization Scheme base on Improved DNA Genetic Algorithm

Contact Info

Product

Resources

About