A New Drug for the Treatment of Fascioliasis in Sheep and Cattle

Broome, A. W. J.; Jones, William G.

doi:10.1038/210744a0

Cited by 27 publications

(5 citation statements)

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“…Since no vaccine has been successfully developed, the effective strategy for controlling fascioliasis depends mainly on the use of pharmaceuticals (fasciolicide). Oxyclozanide was developed in 1966 (6) and has achieved an effective effect in subsequent clinical applications (7, 8). In clinical trials, oxyclozanide has been found to be effective not only for the treatment of F. hepatica infection but also for other tissue parasites, such as Hymenolepis sp.…”

Section: Introductionmentioning

confidence: 99%

Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

et al. 2019

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Oxyclozanide is an effective anthelmintic and has shown good properties in other ways including anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity. This study aimed to investigate the acute and subacute 28-days repeated dose oral toxicity of an oxyclozanide suspension in Wistar rats. A high oral lethal dose (LD50) of 3,707 mg/kg was observed in the acute toxicity test. During the 28-days time period, no obvious adverse effects or death were detected. Histopathological changes were observed in the heart, liver, and kidney of animals treated with high dose of oxyclozanide. Based on the hematological parameters, there were no statistical differences between the oxyclozanide-treated group and the control group. For biochemistry assays, ALP, AST, GLU, TBIL, GLO, TG, BUN, UA, LDH, and CK were statistically changed in the treatment groups. These data suggested that the LD50 of oxyclozanide was ~3,707 mg/kg body weight (BW), and the lowest observed adverse effect level (LOAEL) of oxyclozanide was at a dose of 74 mg/kg in rats.

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Section: Introductionmentioning

confidence: 99%

Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

et al. 2019

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“…Similar 1st-order kinetics have been reported for rafoxanide 2 2 . A small recirculation of closantel and rafoxanide to the central compartment, observed as a slight increase in plasma concentrations 18-48 h after treatment, is most likely caused by an enterohepatic circulation that has been described for this group of drugs 5,12 . Although recirculation of these compounds to and from the gastrointestinal tract, in particular the ruminoreticulum, and recirculation through salivary secretion, may also play a role.…”

Section: Discussionmentioning

confidence: 86%

Intravascular plasma disposition and salivary secretion of closantel and rafoxanide in sheep

Swan¹,

Koeleman²,

Steyn³

et al. 1999

J. S. Afr. Vet. Assoc.

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The plasma and salivary disposition of closantel and rafoxanide were examined following intravenous administration in adult sheep. Two studies were conducted with rafoxanide at 7.5 mg/kg and 1 with closantel using 2 doses (5 and 15 mg/kg). The pharmacokinetic profile of both drugs in plasma were best described by a 2-compartmental model with 1st-order rate constants. Plasma disposition of closantel and rafoxanide were characterised by a rapid distribution (t1/2(a) of <30 min), long elimination half-life (t1/2(b) of 17.0 + 4.0 days for closantel and 7.2 + 0.6 days for rafoxanide), small apparent volume of distribution (Vss of <0.15 ℓ/kg) and a slow rate of total body clearance (Cl of <0.01mℓ/min/kg). The area under the drug plasma concentration curve (AUC) of closantel at 5 mg/kg was nearly twice as large as that of rafoxanide at 7.5 mg/kg resulting from the slower t1/2(b) observed with closantel compared to rafoxanide. Large individual differences were observed in the rate measurements of distribution (k12, k21 and t1/2(a)), whereas the parameters of elimination (k10, t1/2(b) and Cl), were more consistent between animals. A dose proportional increase in AUC was observed for closantel administered at 5 and 15 mg/kg. A low, constant salivary concentration of closantel (mean of 0.04+0.05 mg/mℓ) and rafoxanide (mean of 0.07+0.04 mg/mℓ) was observed during the 24-h examination period after dosing

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“…OCZ, salisilanid grubunda yer alan sığır, koyun ve keçilerde fasciolosis tedavisi ve kontrolünde kullanılan bir antelmentiktir (EMEA, 1998). OCZ'nin glukuronid metaboliti belirlenmiş olmasına rağmen salisilanilidlerin çoğunlukla metabolize olmadığı varsayılmaktadır (Broome & Jones, 1966). Bu metabolit safrada konsantre olmasına rağmen antelmentik olarak aktif değildir (McKellar & Kinabo, 1991).…”

Section: Discussionunclassified

Oksfendazol, oksiklozanid ve oksfendazol-oksiklozanid kombinasyonunun koyun ve keçilerde biyokimyasal ve hematolojik parametreler üzerine etkileri

Kutahya

Kandir

Avci

2022

Veterinary Journal of Mehmet Akif Ersoy University

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Mevcut araştırmada sağlıklı koyun ve keçilere oral yolla oksfendazol, oksiklozanid ve oksfendazol-oksiklozanid kombinasyon uygulamasının, farklı zamanlarda biyokimyasal ve hematolojik parametreler üzerine etkisinin belirlenmesi amaçlandı. Çalışma çapraz dizaynda 6 adet sağlıklı dişi, 1-3 yaştaki İvesi koyun ve Alpin keçi üzerinde gerçekleştirildi. Koyun ve keçilere oral yolla 7.5 mg/kg oksfendazol, 15 mg/kg oksiklozanid ve oksfendazol-oksiklozanid (7.5 mg/kg-15 mg/kg) kombinasyonu uygulandı. Kan örnekleri ilaç uygulamalarından önce (0.saat, kontrol) ve sonraki 8., 24., 72. saat ile 7. günde alındı. Biyokimyasal parametrelerden albümin, alkalen fosfataz, alanin aminotransferaz, aspartat aminotransferaz, kolesterol, trigliserid, total protein, kan üre nitrojen, kreatinin değerleri otoanalizatör cihazında belirlendi. Hematolojik parametrelerden alyuvar sayısı, hemoglobin, hematokrit, ortalama korpüsküler hacim, ortalama korpüsküler hemoglobin, ortalama korpüsküler hemoglobin konsantrasyonu, akyuvar sayısı, lenfosit, monosit, % granülosit, % lenfosit, % monosit ve % eritrosit dağılım genişliği değerleri kan hücresi sayım cihazında ölçüldü. İlaç grupları ve zamana bağlı olarak hematolojik ve serum biyokimya parametrelerinde anlamlı bir fark bulunamadı. Bu sonuçlar koyun ve keçilere oral yolla, 7.5 mg/kg oksfendazol ve 15 mg/kg oksiklozanid tek veya kombine olarak uygulandığında hematolojik ve biyokimyasal parametrelerin fizyolojik sınırlarda olduğu ve klinik olarak anlamlı bir etkisinin olmadığını göstermektedir.

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A New Drug for the Treatment of Fascioliasis in Sheep and Cattle

Cited by 27 publications

References 0 publications

Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats

Intravascular plasma disposition and salivary secretion of closantel and rafoxanide in sheep

Oksfendazol, oksiklozanid ve oksfendazol-oksiklozanid kombinasyonunun koyun ve keçilerde biyokimyasal ve hematolojik parametreler üzerine etkileri

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