A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor

Moghaddam, Ali Zeraatkar; Zamani, Hassan Ali; Karimi-Maleh, Hassan

doi:10.3390/mi12040437

Cited by 26 publications

(16 citation statements)

References 69 publications

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“…On the other hand, since taking dasatinib can cause high risks for the patients, increasing higher risk of infections, which corresponds to a drop in white blood cells (WBCs), it is very important for the the patients to be under the control of a nurse or physician. 16,17 According to a study, a combination of doxorubicin and dasatinib helps treat breast cancer, 18 and thus it may be one of the acceptable approaches for inhibiting or decreasing proliferation, migration, invasion of the breast cancer cells, and cell metabolism. Moreover, this combined therapy would be beneficial for declining drug resistance and unwanted consequences.…”

Section: Introductionmentioning

confidence: 99%

Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Tajik

Afshar

Shamsaddini

et al. 2022

Ind. Eng. Chem. Res.

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Cancer treatment by chemotherapy exploits one or more anticancer drugs to kill cancer cells. Because of the various side effects of chemotherapy drugs, sensitive determination of these drugs is one of the greatest challenges of adjuvant therapy. This study introduced the preparation of a selective and sensitive electrochemical sensor based on a carbon paste electrode (CPE) modified with Fe 3 O 4 @MoS 2 /reduced graphene oxide nanocomposite and ionic liquid (IL) (Fe 3 O 4 @MoS 2 /rGO/ILCPE) to determine dasatinib in the presence of doxorubicin. Results showed very good electrocatalytic activities of Fe 3 O 4 @MoS 2 /rGO/ILCPE toward the oxidation of dasatinib in phosphate buffer solution (PBS) (pH 7.0). The differential pulse voltammetry (DPV), chronoamperometry, and cyclic voltammetry (CV) were employed for studying the electrochemical behaviors of dasatinib on the modified electrode. Based on the optimal condition, we observed a linear increase of the voltammetric current by enhancing the dasatinib concentration in ranges between 0.02 μM and 390.0 μM. The detection limit for the dasatinib was equal to 6.0 nM, based on 3S b / m. Moreover, the modified CPE was used for the detection of dasatinib in the presence of doxorubicin. The corresponding electrochemical signals emerged as two well-resolved oxidation peaks with the considerable peak potential differences of 0.38 V. Finally, dasatinib and doxorubicin detection in the real samples were estimated by examining the functionality of our new sensor that showed acceptable recovery.

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Section: Introductionmentioning

confidence: 99%

Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Tajik

Afshar

Shamsaddini

et al. 2022

Ind. Eng. Chem. Res.

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“…Directly after sampling, all samples were stored in a 20 °C freezer. Blood concentrations of Pb (Pb-B) and Cd (Cd-B) were determined by inductively coupled plasma mass spectrometry (ICP-MS) Thermo X7, Thermo Elemental, Winsford, UK [35,36,37]. Total blood Hg was determined in acid-digested samples by cold vapor atomic fluorescence spectrophotometry [38].…”

Section: Biological Analysismentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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Sources of contamination by lead (Pb), cadmium (Cd), and mercury (Hg) are not regulated in Morocco, and have been reported to be responsible for renal effects in two separate cohorts of Moroccan children and teenagers. The aim of the present study was first to compare internal levels of Pb, Cd and Hg and their separate early renal effects between these two cohorts, living in the same urban, industrial and rural areas of Fez city, and second, to determine the early renal effects of chronic co-exposure to a mixture of these toxic metals. The Generalized Linear Model analysis was used to compare the vulnerability of the two groups to toxic metals' exposure, while the JMP 14 analysis was used to investigate high orders of metals interactions to evaluate the effects of the metal's mixture. The mean of blood lead levels (BLLs) was significantly and exclusively higher in urban young children (82.36 Vs. 57.39 µg/l) and may be responsible for the increase in their urinary Retinol-Bending Proteins (RBP) mean (128.15 Vs. 80.82 µg/g creatinine). These results testify to a high vulnerability to lead exposure in comparison to adolescents living in the same environment. Early alteration of the tubular renal function was evidenced in teenagers, due to potentializing interactions increasing levels of urinary RBP. This confirms the high vulnerability of teenagers, compared with young children, to the renal effects of the environmental mixture of lead and cadmium co-exposure.

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“…However, electrochemical analysis has many advantages, including simplicity, repeatability, good stability, high sensitivity, and no need to sample preparation steps compared to other detection techniques mentioned above [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. A drawback of this method is that it suffers from weak selectivity, which is resolved by modifying the electrode surface to improve the sensitivity and selectivity of electrochemical sensors and avoid surface fouling [50][51][52][53][54][55][56][57][58][59][60][61][62][63].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical strategies for detection of Diazinon: A review

Lohrasbi‐Nejad

2022

J. Electrochem. Sci. Eng.

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Diazinon or O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-O,O-diethyl-O-(2- isopropyl-4-methyl-6-pyrimidinyl)- phosphorothioate, was first registered as an insecticide in the U.S. However, it was categorized in the limited group of pesticides due to high toxicity for birds, aquatic animals, and humans. Like other organophosphorus pesticides, this compound exhibits inhibitory effects on acetylcholinesterase enzyme. The inhibition of the enzyme leads to the accumulation of acetylcholine and causes the death of insects. DZN is considered a toxic compound for humans due to its high adsorption via skin and inhalation, which leads to the emergence of different symptoms of toxicity. When DZN is used for plants, the compound residues in crops enter the food chain, and hence, bring about different problems for human health. Moreover, the compound is easily washed by surface water and enters the groundwater. Its entrance into aquatic environments can negatively affect a wide range of non-targeted organisms. Thus, researchers are seeking to find fast and precise methods for the recognition of DZN. The electrochemical method for recognizing the compound in real samples is preferable to other analytical methods. Because this method can be used without spending time preparing the sample, it is simple, fast, and cost-effective. The present study is an overall review describing electrochemical-based methods for the recognition of DZN. Methods of modifying electrodes with CNT, polymers, biomolecules, and the simultaneous use of multiple methods are evaluated and compared. The influential factors contributing to the improvement of the signal response are also explained.

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A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor

Cited by 26 publications

References 69 publications

Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

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Electrochemical strategies for detection of Diazinon: A review

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A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor

Cited by 26 publications

References 69 publications

Fe3O4@MoS2/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Fe3O4@MoS2/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Untitled

Electrochemical strategies for detection of Diazinon: A review

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Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin