A new emerging oral infection: Raoultella planticola in a boy with haematological malignancy

Abstract

Background Oral mucositis is a common complication in pediatric cancer patients, affecting up to 80% of children. Due to neutropenia and disruption of the mucosal barrier, chemotherapy-induced oral mucositis is often complicated by super-infections. Case report A 16-years old male with stage 3 Burkitt's lymphoma developed chemotherapy induced oral mucositis grade 3 (according to WHO scale). Ulcers were quickly growing (reaching a maximum diameter of 3 cm) and became greyish in colour, resulting in dysphagia and pain. A swab of the lesions was taken and microbiological tests were performed. The sample grew for Raoultella planticola, an encapsulated Gram-negative bacterium whose full pathogenic potential still needs to be defined. Treatment: The patient received antibiotic combination therapy with Amikacin and Ceftazidime for 8 days. Complete healing of the lesions and resolution of the symptoms were reached and he completed his antineoplastic therapy without further complications. Follow-up: Twelve months after the infection, he is alive and well, with no oral complaints. Conclusion This is the first report of a Raoultella planticola infection in a patient with chemotherapy induced oral mucositis. This type of infection must be added to the list of organisms to be considered when caring for these patients.

The first case of Raoultella planticola infective endocarditis in a 4 year old child

“…In this report, the literature was also reviewed for any case reports about Raoultella planticola , and all case reports found were reviewed [[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]]. Pediatric cases are summarized in Table 1 [[5], [6], [7], [8], [9]]. For each case, we show the type of antibiotics used and the duration for each course, in addition to the clinical sequalae for each patient.…”

“…Nada and M. Areej [7]Sep 22, 20134Male16 yOral mucositisLesion swabAmikacin & Ceftazidime8 daysCompetentRecoveredItalyE.Bardellini et al. [8]May 23, 20165Male16 mUTIUrineCourse 110 daysCompetentRecoveredSouth KoreaJH Yoon et al. [9]Nov 11, 2014Abbreviations: m: month/s, y: year/s, PN: post-natal day, Abx: Antibiotics, UTI: urinary tract infection, PD: peritoneal dialysis, IOPL: Intraoperative peritoneal lavage, CA: Clavulanic Acid, IV: intravenous, P.O: Oral, IM: intramuscular, CVC: central venous catheter.Course 1: intravenous cefotaxime and ampicillin/sulbactam for 6 days then oral cefpodoxime for 4 days with total of 10 days.* Patient is preterm 28 weeks.Age grouping as follows:0 to <18 Pediatrics.18 to <65 Adults.65 or more Elderly.…”

The role of oral microbiota in the development of oral mucositis in pediatric oncology patients treated with antineoplastic drugs: A systematic review

“…Following the selection process outlined in the PRISMA diagram, 13 studies met the inclusion criteria, and their data were analyzed in this systematic review (Fig. 1) (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52).…”

“…The included studies were published between 1998 and 2021. Among them, 9 were longitudinal studies (5 case-control studies, 4 cohort studies), 2 were retrospective studies, and 2 were case reports/series (Table 1) (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52).…”

Avaliação perioperatória de indivíduos em quimioterapia com necessidade de intervenção cirúrgica odontológica

“…A presença da mucosite oral decorrente de toxicidade do quimioterápico, resulta em solução de continuidade proporcionada pelas úlceras, tornando-se propício para a colonização e disseminação bacterianas (19) . Nos casos de doença oncohematológica, as infecções fúngicas e virais como candidíase oral e a herpes simples podem ser mais prevalentes que mucosite oral durante e a QT (20) .…”