A New Endoscopically Implantable Device (SatiSphere) for Treatment of Obesity—Efficacy, Safety, and Metabolic Effects on Glucose, Insulin, and GLP-1 Levels

Sauer, Nina; Rösch, Thomas; Pezold, J; Reining, F; Anders, Mario; Groth, Stefan; Schachschal, Guido; Mann, Oliver; Aberle, Jens

doi:10.1007/s11695-013-1005-0

Cited by 39 publications

(13 citation statements)

References 22 publications

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“…They also showed that these results resolved and significantly improved over 70% of all co-morbidities [ 34 ]. Another endoluminal mechanical device, the SatiSphere (Endosphere Inc., Columbus, OH, USA), is also implanted into the stomach and duodenum to delay the transit time of food and has shown effective short-term results in the treatment of obesity and metabolic disease [ 35 ].…”

Section: Role Of Malabsorptive Endoscopic Procedures In Obesity Treatmmentioning

confidence: 99%

Recent Trends in Endoscopic Bariatric Therapies

Choi

Chun

2017

Clin Endosc

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Obesity and its associated metabolic diseases including diabetes mellitus are severe medical problems that are increasing in prevalence worldwide and result in significant healthcare expenses. While behavioral and pharmacological treatment approaches are partly effective in the short term, their effects are not long-lasting. Although previous studies have described bariatric surgery as the most effective treatment for obesity, it is associated with morbidity, mortality, and economic burden. Endoluminal interventions performed entirely using gastrointestinal flexible endoscopy offer alternative approaches to the treatment of obesity that are safer and more cost-effective than current surgical approaches. The use of endoluminal techniques in the field of metabolic obesity disease has diverse promising applications including endoscopic gastroplasty, intragastric balloon, endoluminal malabsorptive bariatric procedures, and gastric electrical stimulation (GES) for the modulation of gastric emptying. This review discusses recent trends and roles in endoscopic bariatric therapies using the currently available endoluminal and transgastric technologies.

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Section: Role Of Malabsorptive Endoscopic Procedures In Obesity Treatmmentioning

confidence: 99%

Recent Trends in Endoscopic Bariatric Therapies

Choi

Chun

2017

Clin Endosc

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“…Additionally, the device was associated with delayed glucose absorption, insulin secretion and altered GLP-1 kinetics. 70 Device migration occurred in 10 of 21 study arm patients, with two necessitating emergent surgery. European study is currently ongoing.…”

Section: Small Bowel Endoscopic Proceduresmentioning

confidence: 99%

Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

Jirapinyo

Thompson

2017

Clinical Gastroenterology and Hepatology

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Obesity is a worsening pandemic with numerous related comorbid illnesses. Conservative management including lifestyle modification and medications have limited efficacy. In contradistinction, bariatric surgery is effective, however, with substantial cost and non-negligible morbidity and mortality. As such, a small percentage of eligible patients undergo surgery. Over the past decade, endoscopic bariatric therapies (EBTs) have been introduced as a less invasive option for the treatment of obesity and its related comorbid illnesses. This paper reviews major endoscopic bariatric therapies, their surgical analogues and proposed mechanisms of action. Clinical trial data for each device are also discussed.

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“…One study evaluating 21 SatiSphere patients was prematurely terminated due to high migration rates (the device migrated in 10 patients, requiring 2 laparoscopic operations) [24].…”

Section: Space-occupying Devicesmentioning

confidence: 99%