2019
DOI: 10.1007/s13311-019-00709-4
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A New Era for Surgical Neurotherapeutics

Abstract: Surgical interventions now have the potential to outperform traditional drug treatments in the management of many different neurological disorders. For example, in epilepsy, despite the introduction of more than a dozen new anti-epileptic medications over the past two decades, the overall rates of seizure freedom are unchanged [1,2], whereas responsive neurostimulation is now known to confer significant improvements in seizure reduction and quality of life in these same medically refractory patients [3,4]. Thu… Show more

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Cited by 5 publications
(4 citation statements)
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“…The nonenhanced T1 sequence should allow differentiation between the gray and white matter, such as magnetization-prepared rapid acquisition with gradient-echo acquisitions, so that whole-brain parcellations can be derived. 1 The whole-brain parcellation serves as an automatic means of labeling anatomic structures within the brain. The 2 whole-brain parcellations that are applied most frequently to automated SEEG planning are FreeSurfer 2 , 3 and geodesic information flows (GIF), 4 and each has its own unique advantages and disadvantages.…”
Section: Model Generationmentioning
confidence: 99%
See 1 more Smart Citation
“…The nonenhanced T1 sequence should allow differentiation between the gray and white matter, such as magnetization-prepared rapid acquisition with gradient-echo acquisitions, so that whole-brain parcellations can be derived. 1 The whole-brain parcellation serves as an automatic means of labeling anatomic structures within the brain. The 2 whole-brain parcellations that are applied most frequently to automated SEEG planning are FreeSurfer 2 , 3 and geodesic information flows (GIF), 4 and each has its own unique advantages and disadvantages.…”
Section: Model Generationmentioning
confidence: 99%
“…To date, only a single study has reported on the prospective integration and validation of such software within a clinical workflow. 1 The EpiNav software was integrated as a clinical decision support software to plan SEEG strategies in 13 consecutive patients in whom manual planning was performed independently. The risk scores were computed for the manual and automated implantation plans as a whole and the plan with the lowest overall risk score was selected for surgical implantation.…”
Section: Clinical Applications Of Computer-assisted Planningmentioning
confidence: 99%
“…This is particularly relevant in cases where the genomic context of the mutation may have an impact on gene function and might prove useful for therapeutic development. There does, however, seem to be increasing momentum in this area with new models being proposed and refined [ 10 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, UA is widely regarded as the bioactive molecule underlying the health benefits of pomegranate consumption. More importantly, UA can cross the blood-brain barrier and has been shown to be a powerful neuroprotectant in-vivo against Alzheimer’s and Parkinson’s Disease, ischemic neuronal injury, and brain aging ( Gasperotti et al., 2015 ; Ryu et al., 2016 ; Yuan et al., 2016 ; Ahsan et al., 2019 ; Gong et al., 2019 ; Andreux et al., 2019 ; Chen et al., 2019 ; Kujawska et al., 2020 ).…”
Section: Introductionmentioning
confidence: 99%