2017
DOI: 10.1080/21541264.2017.1345354
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A new era of studying p53-mediated transcription activation

Abstract: To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

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Cited by 1 publication
(2 citation statements)
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“…1 ), it seems feasible for the Pol II-bound monomeric p53 to recruit additional monomers and further aid DNA binding. In addition, our previous 2D classification analysis identified that p53 could mediate Pol II dimerization while no Pol II dimers were detected without p53 61 . These results indicate that Pol II-bound monomeric p53 may hypothetically form dimers to direct Pol II dimerization and facilitate their occupancies on target gene promoters containing pre-bound dimeric p53 (Supplementary Fig.…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…1 ), it seems feasible for the Pol II-bound monomeric p53 to recruit additional monomers and further aid DNA binding. In addition, our previous 2D classification analysis identified that p53 could mediate Pol II dimerization while no Pol II dimers were detected without p53 61 . These results indicate that Pol II-bound monomeric p53 may hypothetically form dimers to direct Pol II dimerization and facilitate their occupancies on target gene promoters containing pre-bound dimeric p53 (Supplementary Fig.…”
Section: Discussionmentioning
confidence: 89%
“…A number of studies have shown that p53 escorts GTFs to recognize promoter DNA and facilitate transcription 23 , 53 , 64 . Our previous docking analysis 6 , 22 , 61 (with superimposed cryo-EM p53/Pol II structure into the closed PIC) indicates the possibility of p53’s co-presence during PIC assembly. This event may occur, because p53’s mobility could help adapt its position without structural clashes when recruiting other PIC components such as TFIIA or TBP/TFIID 23 .…”
Section: Discussionmentioning
confidence: 93%