A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

Abstract

The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside) and three known glycosides [1β,6α-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (liriopeoside A), 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside, and 1α,6β-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β-D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-β-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 μg/mL, while liriopeoside A (LC50 = 82.84 μg/mL) and 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (LC50 = 153.39 μg/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 μg/mL.

Contact Toxicity and Repellency of the Essential Oil of Liriope muscari (DECN.) Bailey against Three Insect Tobacco Storage Pests

“…The dried tuberous roots have been used as the medicinal part of this plant to treat cough, insomnia, astriction and other diseases [13]. Genuine medicinal materials containing this material are mainly distributed in Quanzhou and Putian, Fujian Province [14]. A literature survey has shown that L. muscari has anti-tumor metastatic activity [15], immune functions [16,17], anti-inflammatory [18], anti-thrombotic activity [19], antioxidant activity [20] and nematocidal activity [14].…”

Isolation of nematicidal constituents from essential oil of <i>Kaempferia galanga</i> L rhizome and their activity against <i>Heterodera avenae</i> Wollenweber

“…Many plant constituents and metabolites including essential oils have been investigated for activity against plant-parasitic nematodes [5][6][7][8][9][10][11].…”

Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita

“…Nematode management is generally based upon chemical treatments (soil fumigation, e.g., methylbromide and dichloropropane), but environmental concerns and governmental regulations are now resulting in a strong interest in nematicides of natural origin [3,4]. Plants are a prominent source of new nematicidal chemicals, since many plants have been reported to possess nematicidal activities [5,6,7,8,9,10,11,12,13,14]. A series of nematicidal substances of plant origin such as triglycerides, sesquiterpenoids, alkaloids, steroids, diterpenoids, monoterpenoids, and flavonoids have been identified [3,4,8,9,10,15,16,17,18,19].…”