A new eunicellin-based diterpene from an okinawan soft coral, Cladiella sp.

New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15] The relative configuration of 1 was elucidated mainly by a nuclear Overhauser effect spectroscopy (NOESY) spectrum as compatible with those of 1 offered by computer modeling (Table 2), in which the close contacts of atoms calculated in space were consistent with the NOESY correlations. In the NOESY experiment for 1, H-1 correlated with H-10 and H 3 -20, suggesting that H-1, H-10, and the isopropyl group are situated on the same face as β protons.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15] In our continuing research on new substances from octocorals distributed in the tropical West Pacific Ocean, the chemical constituents of an Indonesian soft coral identified as Cladiella sp. were examined and 11 new eunicellins, cladieunicellins A-F, 10,15) (−)-solenopodin C, and cladielloides A-D, were isolated.…”

Enantioselective Total Syntheses of Three Cladiellins (Eunicellins): A General Approach to the Entire Family of Natural Products

“…The related natural product cladiell‐11‐ene‐3,6,7‐triol was isolated ( Cladiella sp.) and characterized by Uchio and co‐workers, but bioassay data was not reported for this compound 7…”

“…Cladiella‐6,11‐dien‐3‐ol, 3‐acetoxycladiella‐6,11‐diene, and cladiell‐11‐ene‐3,6,7‐triol were selected as synthetic targets 5–7. The isolation of cladiella‐6,11‐dien‐3‐ol from a Pacific soft coral was first reported by Hochlowski and Faulkner5 in 1980, and Shin and co‐workers reported the isolation of 3‐acetoxycladiella‐6,11‐diene from gorgonians of the genus Muricella in 1997;6 both compounds showed high activity in brine‐shrimp lethality assays.…”

Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors

“…Eunicellin-based diterpenoids display a wide range of bioactivities including anti-inflammatory and antitumor activities [1e3], along with several other ecological and agrochemical-related activities, including molluscidal and mollusk-repellant activity [4,5], hemolytic activity [6], inhibition of cell division in fertilized starfish eggs [7], and insect growth inhibitory activity [8].…”