A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases

Sienkiewicz, Michał; Sroka, Kamila; Binienda, Agata; Jurk, Diana; Fichna, Jakub

doi:10.1016/j.arr.2023.102083

Cited by 9 publications

(7 citation statements)

References 187 publications

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Section: Senescent Gut Barriermentioning

confidence: 99%

“…Senescent cells were recently found to play a major role in the pathogenesis of inflammatory bowel disease (IBD), a condition marked by translocation of microbes from the GI tract into the host tissues, including the brain [68]. This is further enhanced by the increased prevalence of SCZ in patients with IBD, emphasizing the role of the GI tract in severe mental illness [68,69]. Microbial translocation has been studied extensively in infection with human immunodeficiency virus (HIV), a condition marked by massive exit of microbes from the GI tract due to deficient interleukin-22 (IL-22) [70].…”

Section: Senescent Gut Barriermentioning

confidence: 99%

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The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Sfera,

Imran,

Sfera

et al. 2024

Preprint

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For the past 70 years, dopamine hypothesis has been the key working model in schizophrenia. This has contributed to the development of numerous inhibitors of dopaminergic signaling, antipsychotic drugs, which led to rapid symptom resolution but only marginal outcome improvement. Over the past decades, there was limited research on the quantifiable pathological changes in schizophrenia, including premature cellular/neuronal, senescence, brain volume loss, attenuation of gamma oscillations on electroencephalogram and oxidation of lipids in plasma and mitochondrial membranes. We surmise that aberrant activation of aryl hydrocarbon receptor by toxins derived from the gut microbes or the environment drives premature cellular, including neuronal, senescence, a hallmark of schizophrenia. Early brain aging promotes secondary changes, including impairment and loss of mitochondria, gray matter depletion, decreased gamma oscillations, and a compensatory metabolic shift to lactate and lactylation. The aim of this narrative review is twofold: 1. To summarize what is known about premature cellular/neuronal senescence in schizophrenia or schizophrenia-like disorders. 2. To discuss novel strategies for improving long-term outcome in severe mental illness with natural senotherapeutics, membrane lipid replacement, mitochondrial transplantation, microbial phenazines, novel antioxidant phenothiazines, inhibitors of glycogen synthase kinase-3 beta, and aryl hydrocarbon receptor.

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Section: Senescent Gut Barriermentioning

confidence: 99%

Section: Senescent Gut Barriermentioning

confidence: 99%

The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Sfera,

Imran,

Sfera

et al. 2024

Preprint

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“…Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Common complications include persistent inflammation, intestinal lesions, particularly of the colorectal and rectal mucosa and submucosa, − and gastrointestinal fibrosis, which can seriously affect patients’ quality of life. , The etiology and pathogenesis of IBD are not fully understood; however, current research suggests that it is a multigenic disease associated with abnormal immune function, intestinal infections, genetic factors, intestinal flora, and other factors. − Clinical treatments for IBD include anti-inflammatory drugs and biopharmaceuticals to reduce colonic mucosal and systemic inflammation and regulate the immune response. However, owing to the chronic nature of IBD and the adverse side effects of these drugs, the clinical effectiveness of IBD treatments is limited. , Consequently, there is an urgent need for further research and development of appropriate drugs and drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 6 The etiology and pathogenesis of IBD are not fully understood; however, current research suggests that it is a multigenic disease associated with abnormal immune function, intestinal infections, genetic factors, intestinal flora, and other factors. 7 − 9 Clinical treatments for IBD include anti-inflammatory drugs and biopharmaceuticals to reduce colonic mucosal and systemic inflammation and regulate the immune response. However, owing to the chronic nature of IBD and the adverse side effects of these drugs, the clinical effectiveness of IBD treatments is limited.…”

Section: Introductionmentioning

confidence: 99%

Curcumin@Fe/Tannic Acid Complex Nanoparticles for Inflammatory Bowel Disease Treatment

Jin,

Ye,

Huang

et al. 2024

ACS Omega

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Inflammatory bowel disease (IBD) is a serious public health issue because of its chronic and incurable nature. Common IBD drugs have limited efficacy and produce adverse effects, leading to an urgent need to develop new drugs and drug delivery systems. Curcumin (Cur) is a natural and nontoxic drug that is increasingly used in the treatment of IBD owing to its antiinflammatory and antioxidant effects. Metal−polyphenol networks constructed from metal ions and polyphenols exhibit biological functionality while acting as an adhesive nanomaterial to encapsulate nano-Cur, thereby improving its solubility and drug release behavior. In this study, we prepared a Cur@Fe&TA nanodrug delivery system by constructing an Fe 3+ /tannic acid (TA) metal−polyphenol network with encapsulated Cur. The Cur@ Fe&TA nanodrug exhibited good stability, drug release behavior, and biocompatibility. Based on the anti-inflammatory and antioxidant effects of Cur@Fe&TA, the gastrointestinal cytopathology in an IBD mouse model was effectively improved. The proposed Cur@Fe&TA nanomedicine delivery system has promising application and research value for the treatment of IBD by regulating levels of antioxidants and inflammatory cytokines.

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“…The imbalance of the intestinal mucosal immune equilibrium leads to mucosal instability, tissue damage, and the onset of chronic in ammation. Immune cells such as neutrophils, monocytes, macrophages, and T cells release various in ammatory factors, causing tissue damage and systemic in ammatory responses [5]. In addition to the gastrointestinal symptoms, patients with IBD often experience accompanying symptoms in the nervous system, including depression and anxiety [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Upregulation of MMP9 and ORM2 leading to increased neutrophil infiltration as a potential common mechanism in the development of IBD and MDD

Sun,

Gao,

et al. 2024

Preprint

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Major depressive disorder (MDD) is an emotional distinguished by core clinical symptoms such as low mood, diminished interest, lack of pleasure, reduced activity, and mental inhibition. Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract with with an unknown etiology. Previous studies have indicated a positive association between MDD and IBD, although the specific underlying mechanism remains unclear. The objective of this research was to investigate shared differentially expressed genes (DEGs) common to MDD and IBD through bioinformatics analysis to elucidate the connection.The series matrix files of GSE3365 and GSE98793 were obtained from the NCBI GEO public database. The limma R package was utilized to identify DEGs common to MDD and IBD. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional annotation, protein–protein interaction analysis of the hub genes, weighted gene co-expression network analysis (WGCNA), correlation analysis of the hub genes with immune responses, and analysis of immune infiltrations were conducted. Gene set enrichment analysis was performed to elucidate the underlying pathogenesis. The intersection analysis identified 27 commonly upregulated genes and 13 downregulated genes. Subsequent GO and KEGG analyses revealed enrichment of infection-related signaling pathways among the DEGs. The integration of genes from the WGCNA module and differential genes resulted in the identification of eight commonly upregulated genes: PROS1, ORM2, SLP1, MMP9, CLEC5A, ARG1, OLR1, and EGF. Furthermore, immune infiltration analysis demonstrated an increase in neutrophil infiltration in both the MDD and IBD datasets. ORM2 and MMP9 were found to be correlated with neutrophil infiltration. These pivotal genes, associated with neutrophils and monocytes, play crucial roles in the pathophysiology of both conditions. Targeting ORM2 and MMP9 may hold promise as potential diagnostic and therapeutic strategies for managing the comorbidity of IBD and MDD.

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A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases

Cited by 9 publications

References 187 publications

The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

The Future of Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes

Curcumin@Fe/Tannic Acid Complex Nanoparticles for Inflammatory Bowel Disease Treatment

Upregulation of MMP9 and ORM2 leading to increased neutrophil infiltration as a potential common mechanism in the development of IBD and MDD

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