A new factor in pathogenesis of edema of cardiac origin

Wégria, René; Entrup, RW; Jue, J.; Hughes, Meagan

doi:10.1152/ajplegacy.1967.213.1.94

Cited by 14 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study might be less invasive compared to others, so that such a threshold phenomenon could be observed more frequently. This mechanism might work as a safety factor to minimize oedema formation in pathologically increased lymph flow conditions such as heart failure (F oldi & Papp, 1961;W egria, Entrup, Jue & Hughes, 1967). Sakai et al (1985) observed that in anaesthetized dogs thoracic duct lymph flow as measured with heated crossthermocouples continuously increased during saline infusion in spite of a marked rise in central venous pressure to about 40 cmHµO.…”

Section: Effect Of Outflow Venous Pressurementioning

confidence: 99%

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Onizuka

Flatebø

Nicolaysen

1997

The Journal of Physiology

View full text Add to dashboard Cite

To study the lymph flow dynamics in the intact thoracic duct, we applied an ultrasound transit‐time flow probe in seven anaesthetized and four unanaesthetized adult sheep (.60 kg). In unanaesthetized non‐fasting animals we found that lymph flow in the thoracic duct was always regular pulsatile (pulsation frequency, 5.2 ± 0.8 min−1) with no relation to heart or respiratory activity. At baseline the peak level of the thoracic duct pulse flow was 11.6–20.7 ml min−1 with a nadir of 0–3.6 ml min−1. Mean lymph flow was 5.4 ± 3.1 ml min−1. The flow pattern of lymph in the thoracic duct was essentially the same in the anaesthetized animals. In both the anaesthetized and unanaesthetized animals, the lymph flow response to a stepwise increase in the outflow venous pressure showed interindividual variation. Some were sensitive to any increase in outflow venous pressure, but others were resistant in that lymph flow did not decrease until outflow venous pressure was increased to higher levels. This resistance was also observed in the high lymph flow condition produced by fluid infusion in the anaesthetized animal and mechanical constriction of the caudal vena cava in the unanaesthetized animals. Pulsation frequency of the thoracic duct flow initially increased and then decreased with a stepwise increase in the outflow venous pressure. This initial increase might be a compensatory response to maintain lymph flow against elevated outflow venous pressure. To test the effect of long‐term outflow venous pressure elevation in unanaesthetized sheep, outflow venous pressure was increased by inflation of a cuff around the cranial vena cava for 1, 5 or 25 h. The cuff was inflated to a level where lymph flow was reduced. Lymph flow remained low or decreased further during the entire cuff‐inflation period. We calculated the lymph debt caused by the outflow venous pressure elevation and the amount ‘repaid’ when venous pressure returned to normal. Lymph debt for 25 h was 6400 ml but only 200 ml was repaid. Since we observed no visible oedema formation in the lower body of the sheep, the non‐colloidal components of the lymph must have been reabsorbed into the bloodstream, most likely in the lymph nodes.

show abstract

Section: Effect Of Outflow Venous Pressurementioning

confidence: 99%

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Onizuka

Flatebø

Nicolaysen

1997

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Both of these reactions at the levels studied shared a characteristic which features in part, at least, an impairment of the removal of macromolecules from the pleural space. That such a phenomenon may be pathogenetically important in the collection of interstitial fluid is supported by observations that the accumulation of fluid in cardiac edema in the dog (17) and ascites in the rat with portal hypertension (18) is dependent upon some degree of lymphatic (sic, outflow) obstruction.…”

Section: Figs 1 and 2 Show Results Of Inflow Of -Y-globulin-'imentioning

confidence: 91%

A physiologic differentiation between delayed and immediate hypersensitivity

Apicella¹,

Allen²

1969

J. Clin. Invest.

View full text Add to dashboard Cite

“…It would appear that the degree of restriction to exchange of solutes across the pulmonary capillary endothelium is quite similar to that which is observed in the endothelium of heart and skeletal muscle capillaries. Obstruction to increased lymph flow by a rise in left atrial pressure increases the likelihood of the development of pulmonary edema (33) and, as noted above, might be expected to be especially hazardous in association with a major septic focus. (26) Calculations of pore size indicate that the pores of the pulmonary capillary endothelial membrane (40-50 Ä) are approximately 7-10 times larger than those of the alveolar epithelial membrane (6-10 Ä), a finding which is consistent with the differences in permeability at these two sites.…”

Section: Transcapillary Fluid Exchange Of Water Sodium and Protementioning

confidence: 97%

Surgical Aspects of Albumin Metabolism

Skillman

1977

Albumin: Structure, Function and Uses

View full text Add to dashboard Cite

A new factor in pathogenesis of edema of cardiac origin

Cited by 14 publications

References 0 publications

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

Lymph Flow Pattern in the Intact Thoracic Duct in Sheep

A physiologic differentiation between delayed and immediate hypersensitivity

Surgical Aspects of Albumin Metabolism

Contact Info

Product

Resources

About