A new familial presentation of dissecting cellulitis: The genetic implications on scarring alopecias

Díaz-Pérez, Lily Michel; Escobar-Ramírez, Karina; Sánchez-Dueñas, Luis Enrique

doi:10.1016/j.jdcr.2020.05.027

Cited by 8 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, three studies described combined medical and procedural treatments in four patients. Of the three studies, two examined intralesional steroid injection use combined with various doses of isotretinoin [ 49 , 50 ]. All three patients improved.…”

Section: Procedural Treatmentsmentioning

confidence: 99%

Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm

Masson,

Jeong,

et al. 2023

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Background Dissecting cellulitis of the scalp (DCS) is a chronic inflammatory skin condition characterized by abscesses, nodules, fistulas, and scarring alopecia. Management of this oftentimes debilitating dermatosis can be challenging due to its recalcitrant nature. There is limited data regarding the efficacy of treatment options for DCS. Objective The aim of this study was to conduct a systematic review of the literature to explore the efficacy and safety of reported DCS treatments. Methods In October 2022, MEDLINE and EMBASE databases were searched for articles on treatments for DCS. Studies that contained outcome efficacy data for DCS treatments were included. Reviews, conference abstracts, meta-analyses, commentaries, non-relevant articles, and articles with no full-text available were excluded. Data extraction was performed by two independent reviewers. Results A total of 110 relevant articles with 417 patients were identified. A majority of studies (86.4%) were case reports or series. Treatment options included systemic antibiotics, oral retinoids, biologics, procedural treatments, combination agents, and topical treatments. Oral retinoids and photodynamic therapy were the most extensively studied medical and procedural interventions, respectively. Conclusion Overall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy.

show abstract

Section: Procedural Treatmentsmentioning

confidence: 99%

Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm

Masson,

Jeong,

et al. 2023

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…The fact of PCAS occurring in monozygous twins could be seen as an example supporting the hypothesis of genetic background. 6 A study published in Science identified independent loss-of function mutations in PSENEN, PSEN1 or NCSTN, whose proteins are essential components of the γ-secretase multiprotein complex, implicating the γ-secretase-Notch pathway in the molecular pathogenesis of HS. 7 However, the specific genetic mechanism needs to be further explored in PCAS.…”

mentioning

confidence: 99%

Therapeutic options for perifolliculitis capitis abscedens et suffodens: A review

Zhang

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

Perifolliculitis capitis abscedens et suffodiens (PCAS) is a chronic skin inflammatory disease characterized by relapsing folliculitis and painful, fluctuant abscesses, sinus tracts, and scars. The treatment of PCAS is challenging and clinical practice varies a lot, and how to choose the best treatment for PCAS is a real problem for clinicians. We reviewed articles providing treatment options for patients with PCAS in different databases. Dermatologists may find this review helpful to meet the challenges of PCAS management, but there is still a lack of authoritative guidelines. In the future, more robust randomized control trials are needed to determine the best treatment for PCAS. K E Y W O R D S biologics, dissecting cellulitis of the scalp (DCS), perifolliculitis capitis abscedens et suffodiens (PCAS), retinoids, treatment option 1 | INTRODUCTION Perifolliculitis capitis abscedens et suffodiens (PCAS), also known as dissecting cellulitis of the scalp (DCS) or Hoffman's disease, is a chronic skin inflammatory disease characterized by relapsing folliculitis and painful, fluctuant abscesses in the scalp that lead to the formation of sinus tracts and scarring. 1 PCAS may occur along with hidradenitis suppurativa (HS), acne conglobate and pilonidal sinus, termed the follicular occlusion tetrad. These four different clinical conditions appear to have common pathogenic events including follicular hyperkeratosis, poral obstruction, dilation and rupture, followed by neutrophilic and granulomatous inflammatory response, bacterial overgrowth, scarring, and sinus tract formations. 2 Treatment of PCAS is challenging and clinical practice varies a lot, while evidence-based treatment guidelines for PCAS are quite rare. Despite a paucity of robust and high-quality data on PCAS, this review focuses on different aspects of PCAS, especially on treatment options for PCAS, providing clinical inspirations for dermatologists. | CLINICAL MANIFESTATIONS AND HISTOPATHOLOGIC FEATURESLesions of PCAS are folliculitis at an early stage and becoming nodules and abscesses later, primarily on the occipital scalp or vertex, with symptoms of pain, itching or swelling. The nodules and abscesses rapidly develop into interconnecting, fluctuant, boggy sinus tracts, which discharge purulent and bloody secretions with a foul smell. With time, irreversible atrophic or hypertrophic scarring and cicatricial alopecia occur. PCAS presents as a chronic process with frequent episodes. 1,3 The histopathologic characteristics of PCAS usually depend on the clinical manifestation, which can range from early folliculitis, nodules or abscesses to sinus tracts or scars. In the early stage, histopathology findings show an infiltrate of lymphocytes and neutrophils involving the lower half of the dermis and gradually extended downward to subcutaneous fat. The disease progressed with vascular hyperplasia. In the late stage, the deep dermis and subcutaneous fat layer show the histologic characteristics of granuloma and eventually sinus tract and fibrosis develop. 4,5

show abstract

Acquired Disorders of Hair

Harries,

Holmes,

McMichael

et al. 2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

This chapter reviews acquired hair disorders, including common scarring and non‐scarring alopecia presentations, conditions characterised by excessive body hair growth and acquired hair shaft disorders. We also describe the biology of normal hair follicles, including structure, hair cycle control and immunity, to better understand the mechanisms underlying these conditions. We present methods for clinical assessment, recommended investigation and management of each disease, and present summaries of frequently used therapeutics and cosmetic options employed when treating these problems.

show abstract

A new familial presentation of dissecting cellulitis: The genetic implications on scarring alopecias

Cited by 8 publications

References 10 publications

Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm

Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm

Therapeutic options for perifolliculitis capitis abscedens et suffodens: A review

Acquired Disorders of Hair

Contact Info

Product

Resources

About