A new family of Ru(ii) complexes with a tridentate pyridine Schiff-base ligand and bidentate co-ligands: synthesis, characterization, structure and in vitro cytotoxicity studies

Structural Determination of Ruthenium Complexes Containing Bi-Dentate Pyrrole-Ketone Ligands

“…Ruthenium compounds [ 1 , 2 , 3 ] containing varieties of ligands, such as cymene [ 4 , 5 ], phosphine [ 6 ] NHC [ 7 ], keto-amine [ 8 , 9 ], and Schiff-base [ 10 , 11 ], represent an important chemical series on the field of medicinal chemistry [ 12 , 13 , 14 , 15 ] and catalytic transfer hydrogenation [ 16 , 17 , 18 ] etc. Finely tuned ruthenium complexes can be achieved by changing the coordinating ligands.…”

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

“…Recent research largely illustrates that the in vitro and in vivo properties of ruthenium compounds can be finely tuned by ligand variation. Intense investigations converge on ligand selection from the arene, phosphine, aromatic heterocycles, pyridine, pta, pybox, pyrazolone-based β-ketoamine, nitrosyl, Schiff-base, carboxamide, carbothioamide, thiourea, thiocarbamate, thiosemicarbazone, and hydrazone classes [36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78]. Innovations were applied to construct coordination-driven self-assembled arene-Ru metalla-rectangles endowed with stronger cytotoxicity against all cancer cell lines and even more effective than established anticancer drugs like doxorubicin and cisplatin [50].…”

Reactivity of Dinuclear Copper(II) Complexes with N‐Salicylidene Glycine Schiff Bases as Carboxylesterase Models

“…Especially, amino acid Schiff bases and corresponding metal complexes were attracted attention due to the physiologically activity and compatibility of amino acids . However, it is noteworthy that main aspects of the relevant researches only concentrated on the synthesis, structural analysis, as well potential medicinal values of metal complexes with various amino acid Schiff bases.…”