A ten-dimensional super-Poincaré covariant formalism for the superstring was recently developed which involves a BRST operator constructed from superspace matter variables and a pure spinor ghost variable. A super-Poincaré covariant prescription was defined for computing tree amplitudes and was shown to coincide with the standard RNS prescription.In this paper, picture-changing operators are used to define functional integration over the pure spinor ghosts and and to construct a suitable b ghost. A super-Poincaré covariant prescription is then given for the computation of N -point multiloop amplitudes. One can easily prove that massless N -point multiloop amplitudes vanish for N < 4, confirming the perturbative finiteness of superstring theory. One can also prove the Type IIB S-duality conjecture that R 4 terms in the effective action receive no perturbative contributions above one loop.