A New Flavanone from the Leaves of Chromolaena odorata

Abstract

Chromolaena odorata (Syn: Eupatorium odoratum) is a perennial plant belonging to the Asteraceae family. Extracts of C. odorata have shown strong anti-oxidant and moderate anti-adipogenenesis activities. Detailed phytochemical investigation of C. odorata led to the isolation of 21 secondary metabolites, which include a new flavanone (3), and a chalcone, 3,2-dihydroxy-4,4,5,6-tetramethoxychalcone (2), reported for the first time from a natural source, besides three known compounds 1, 4 and 5, all of which are reported for the first time from C. odorata. Some of these compounds exhibited potent anti-oxidant and anti-adipogenesis activities and these may be partly responsible for the activity of the extract.

Wound healing property review of siam weed, Chromolaena odorata

“…The dried leaf of C. odorata contained ash (11%), crude fat (11%), fiber (15%), moisture (15%), crude protein (18%), and carbohydrate (31%). [ 23 ] Its active phytochemical substances are as follows: (1) flavonoid aglycones (flavanones, flavonols, flavones) including acacetin, chalcones, eupatilin, luteolin, naringenin, kaempferol, quercetin, quercetagetin, and sinensetin;[ 24 25 26 27 28 29 30 31 ] (2) terpenes and terpenoids;[ 32 ] (3) essential oils;[ 33 34 35 36 37 38 ] (4) alkaloids including pyrrolizidine;[ 39 40 41 ] (5) saponins and tannins;[ 23 ] (6) phenolic acids including ferulic acid, protocatechuic acid;[ 42 ] (7) phytoprostane compound including chromomoric acid. [ 43 ]…”

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

“…In Myanmar, local people are used for stomachache, cancer, and urinary tract infection. Chemical components of this plant have been discovered as chalcones, flavonoids, glycosides, anthraquinones, triterpenoids, fatty acids, coumarino lignoids, and phenolic compounds [4][5][6][7][8][9][10][11][12].…”

“…In Myanmar, it is used to treat diarrhea (seeds) and liver disorders (barks). Phytochemical studies of C. oblongifolius have been reported in several different types of research and many clerodane diterpenes, cembranoid diterpenes, halimane-type diterpenoids, labdane diterpenoids, furanocembranoids, and megastigmane glycosides have been isolated from the stem barks, leaves, and roots [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”