A New Flavanone Glucoside from Oroxylum indicum

Sarma, Indrajit Sil; Ghosh, Partha; Banik, Rajarshi; Dinda, Biswanath

doi:10.1007/s10600-015-1431-4

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…In recent years, different parts of O. indicum (L.) Vent have been used in traditional medicine because they exhibit various biological activities, such as antiinflammatory [1][2][3], antibacterial [4][5][6][7], anticancer [2,[8][9][10], and anti-atherosclerosis [11], In addition, O. indicum (L.) Vent has been used as an expectorant, for protecting liver function [12][13][14], treating hypoglycemia, preventing and treating cataracts and liver cancer [15][16][17][18], and protecting nervous system function [19][20][21]. The chemical constituents of O. indicum (L.) Vent are complex, but the main components are flavonoid aglycones, flavonoid glycosides, rosewood alkaloids, and volatile oils, as well as specific compounds such as p-hydroxyphenylethanol and cyclohexanol [15,[22][23][24]. The predominant biologically active chemical components of O. indicum (L.) Vent are oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-Obeta-gentiobioside, and guaijaverin [23].…”

Section: Introductionmentioning

confidence: 99%

Determination of oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin in mouse blood by UPLC-MS/MS and its application to pharmacokinetics

Zheng

Fan

Jin

et al. 2022

AChrom

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In this study, a UPLC-MS/MS method was developed to measure the concentrations of the flavonoids oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin in the blank mouse blood, and the method was then used in the measurement of the pharmacokinetics of the compounds in mice. Oroxin A, oroxin B, oroxylin A, oroxyloside, chrysin, chrysin 7-O-beta-gentiobioside, and guaijaverin were administered intravenously at a dose of 5 mg kg−1, and the mouse blood (20 μL) was withdrawn from the caudal vein 0.08333, 0.25, 0.5, 1, 2, 4, 6, 8, and 10 h after administration. The mobile phase used for chromatographic separation by gradient elution was composed of acetonitrile and water (0.1% formic acid). The analytes were detected by operating in electrospray ionization (ESI) positive-ion mode using multiple reactions monitoring (MRM). The intra-day and inter-day accuracy ranged from 86.2 to 109.3%, the intra-day precision was less than 14%, and the inter-day precision was less than 15%. The matrix effect ranged from 85.3 to 111.3%, and the recovery of the analytes after protein precipitation were all above 78.2%. This method had the advantages of high sensitivity, accuracy, and recovery, and it had excellent selectivity, which enabled it to be applied to measuring the pharmacokinetics of the analytes in mice.

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