A new flavonoid and other constituents fromCentaurea nicaeensisAll. var.wallianaM.

Abstract

A new flavone glucoside, apigenin 4'-(6″-methylglucuronide) (1), together with six known compounds, cirsilineol, jaceosidin, melitensin, apigenin, apigenin 7-(6″-methylglucuronide) and prunasin, were isolated from the ethanolic extract of the aerial parts of Centaurea nicaeensis All. var. walliana M. (Asteraceae) collected from Souk-Ahras, eastern Algeria. The structures were established by spectral analysis, mainly HRESI-MS, UV and 2D-NMR experiments (COSY, HSQC and HMBC).

Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high‐fat diet and analyses of the metabolites originating from these two polymethoxylated flavones

“…Each of these showed neutral losses of 176 amu (presumed glucuronic acid‐H 2 O) in their positive ion ESI‐MS. Four metabolites (O‐R) exhibited neutral losses of 190 amu (Figure 6), which are tentatively assigned to the losses of methylglucuronide (Hammoud et al., 2012; Nazaruk & Jakoniuk, 2005; Rodriguez Lanzi et al., 2018; Serra et al., 2009).…”

“…The results in Table 6 show the degrees of desmethylation of the flavone A-and B-rings (Berahia et al, 1994;Chen et al, 1997;Rizzi & Boeing, 1984). Three di-desmethylHMF aglycones (A-C) and three mono-desmethylHMF aglycones (D-F) were detected (Figure 5), and later isolated for pre- 6), which are tentatively assigned to the losses of methylglucuronide (Hammoud et al, 2012;Nazaruk & Jakoniuk, 2005;Rodriguez Lanzi et al, 2018;Serra et al, 2009).…”

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

“…The highest cytotoxic effect was obtained from the ethyl acetate fraction. In their study using the plant C. arenaria, following advanced chromatographic experiments, Hammoud et al (2012) performed a structural analysis of the samples gathered using NMR and researched the cytotoxic effects of 16 materials on the HeLa cervical cancer cell line, the MCF- 7 breast cancer cell line, and the A431 epidermal cancer cell line. The ethyl acetate fraction obtained in this study had a cytotoxic effect on the MCF-7 breast cancer cell line, according to advanced chromatographic technologies.…”

Phenolic Profile of Artemisia alba Turra

“…alba by column chromatography (CC) on Sephadex LH‐20 and subsequent CC and PTLC of the obtained fractions (see Experimental Section). The identification of chlorogenic acid, 3,5‐ and 4,5‐dicaffeoylquinic acids, scopoletin, umbeliferone, luteolin, nepetin, quercetin 3‐methyl ether, axillarin, apigenin, hispidulin, diosmetin, chrysoeriol, desmethoxycentaureidin, jaceosidin, quercetin 3,3′‐dimethyl ether, centaureidin, and rutin was achieved by comparison of their 1 H‐NMR, MS, and UV spectral data with those published in the literature and/or with authentic standards. Their structures are presented in Figure .…”