A New Flavonol Glycoside from Seeds of Cassia multijuga

Dubey, P.; Gupta, P. C.

doi:10.1055/s-2008-1074855

Cited by 6 publications

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“…Several chemical studies of seeds, leaves, and roots have shown the occurrence of flavonoids, anthraquinones, , polysaccharides, and chromones . In Brazil, this species is popularly known as “pau-cigarra”, “caquera”, “topeiuia”, “aleluia”, and “canafístula” and is used as an ornamental plant in several regions of the country due to its attractive yellow flowers. , Although some species of the Senna ( Cassia ) genus have been reported to be an important source of phenolic compounds with diverse biological and pharmacological properties, only the seeds of S. multijuga are used for the treatment of ophthalmic and skin infections . However, no phytochemical study on the isolation of the secondary metabolites of this species has been conducted previously.…”

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Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

et al. 2009

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Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone (2), were isolated from the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established on the basis of spectroscopic data interpretation. Compounds 1 and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison with the standard compound physostigmine.

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Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

et al. 2009

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“…4 Regarding its ethnobotanical utilization, S. multijuga leaves have been used as a sedative by indigenous tribes during rituals. 3 Previous phytochemical studies have demonstrated the presence of flavonoid glycosides and pyridine alkaloids in this species, with these substances shown to exhibit moderate acetylcholinesterase (AChE) inhibitory activity. 5 A further investigation on the leaves of S. multijuga was carried out, in the hope of finding new unusual pyridine alkaloids in an EtOH extract of these leaves and to evaluate their action as AChE inhibitors.…”

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“…(Fabaceae, Caesalpinioideae), popularly known as “aleluia”, “canafístula”, “caquera”, “pau-cigarra”, and “topeiuia”, is a common tree in the Brazilian Atlantic Forest and other biomes in Africa . It is widely used for ornamental decoration because of its attractive yellow flowers and evergreen leaves . In Brazil, medicinal applications have not been reported frequently for this species, although aqueous preparations from its seeds have been employed in the treatment of ophthalmic and skin infections, which provides evidence of potential antimicrobial properties .…”

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“…Regarding its ethnobotanical utilization, S . multijuga leaves have been used as a sedative by indigenous tribes during rituals . Previous phytochemical studies have demonstrated the presence of flavonoid glycosides and pyridine alkaloids in this species, with these substances shown to exhibit moderate acetylcholinesterase (AChE) inhibitory activity .…”

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confidence: 99%

“…2 It is widely used for ornamental decoration because of its attractive yellow flowers and evergreen leaves. 3 In Brazil, medicinal applications have not been reported frequently for this species, although aqueous preparations from its seeds have been employed in the treatment of ophthalmic and skin infections, which provides evidence of potential antimicrobial properties. 4 Regarding its ethnobotanical utilization, S. multijuga leaves have been used as a sedative by indigenous tribes during rituals.…”

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Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors

et al. 2012

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As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassiamultijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine.

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The genusCassiaL.: Ethnopharmacological and phytochemical overview

Khurm

Wang

Zhang

et al. 2020

Phytotherapy Research

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after first online publication: The funding information and acknowledgement sections have been updated in this version.] Nature gifts medicinal plants with the untapped and boundless treasure of active chemical constituents with significant therapeutic potential that makes these plants a beneficial source in the development of phytomedicines. Genus Cassia, with approximately 500 species, is a large group of flowering plants in the family Fabaceae. Cassia species are widely distributed throughout different regions mainly tropical Asia, North America, and East Africa. In the folk medicinal history, these plants are used as laxative and purgative agents. In the Ayurveda system of medicine, they are used to cure headache and fever. Cassia plants exhibit pharmacological activities at large scales such as antimicrobial, anticancer, antiinflammatory, antioxidant, hypoglycemic, hyperglycemic, antimutagenic, and antivirals. The phytochemical investigations of genus Cassia demonstrate the presence of more than 200 chemical compounds, including piperidine alkaloids, anthracene derivatives (anthraquinones), flavonoids, pentacyclic triterpenoids, sterols, phenylpropanoids, and γ-naphthopyrones. The literature illustrated anthraquinones and flavonoids as major secondary metabolites from this genus. However, some Cassia plants, with rich contents of anthraquinones, still show toxicology properties. As Cassia plants are used extensively in the herbal Abbreviations: AAE, ascorbic acid equivalent; AGEs, advanced glycation end products; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase enzyme; CCl4, carbon tetrachloride; CFU, colony forming units; COLO320DM, human colon carcinoma cell line; CRFK, crandell feline kidney cell; DMSO, dimethyl sulfoxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; EC 50 , half maximal effective concentration; ELISA, enzyme-linked immunosorbent assay; FDA, Food and Drug Administration; GPx, glutathione peroxidase; HCT-116, human colorectal carcinoma cell line; HDL, high-density lipoprotein; HeLa, immortal cell line used in scientific research; HEL, human erythroleukemia cell line; Hep-2, human epithelial type 2 cells; HIV,

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A New Flavonol Glycoside from Seeds of Cassia multijuga

Abstract: A new flavonol glycoside cassiglucin isorhamnetin-3-0-P-D-galactopyranoyl-0-P-D-glucoside) has been isolated rom the seeds of Cassia multijuga. ntroduction Cassia multijuga possesses important nedicinal properties [I]. Its seeds are ~sed in the treatment of o~h t h a l m i a

Cited by 6 publications

References 1 publication

Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors

The genusCassiaL.: Ethnopharmacological and phytochemical overview

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