A new fluorescent biosensor based on inner filter effect and competitive coordination with the europium ion of non-luminescent Eu-MOF nanosheets for the determination of alkaline phosphatase activity in human serum

Hu, Shuisheng; Liu, Jingyan; Wang, Yong; Liang, Zhiguang; Hu, Bin; Xie, Jing; Wong, Wing‐Leung; Wong, Kwok Yin; Qiu, Bin; Peng, Wei

doi:10.1016/j.snb.2023.133379

Cited by 18 publications

(5 citation statements)

References 45 publications

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“…In addition, the developed bioprobe showed selectivity to DA only, as shown by the highest quenching efficiency compared with other interferants, such as metal ions, amino acids, macromolecules, and neurotransmitters. Among the several nanomaterials, the metal–organic framework (MOF) has attracted considerable attention from researchers in the biosensor field [ 93 , 94 ]. The MOF has unique properties and advantages in biosensing compared with other nanomaterials, such as (i) enabling target binding with probe molecules via π-π stacking [ 95 ], (ii) high surface area with porosity [ 96 ], (iii) easy functionalization and tailoring by controlling the ratio of metal ions in the MOF [ 97 ], and (iv) stability [ 98 ].…”

Section: Enzymatic Fluorescent Nanobiosensorsmentioning

confidence: 99%

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Choi

Yoon

2023

Biosensors

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The detection of small molecules has attracted enormous interest in various fields, including the chemical, biological, and healthcare fields. In order to achieve such detection with high accuracy, up to now, various types of biosensors have been developed. Among those biosensors, enzymatic biosensors have shown excellent sensing performances via their highly specific enzymatic reactions with small chemical molecules. As techniques used to implement the sensing function of such enzymatic biosensors, electrochemical and fluorescence techniques have been mostly used for the detection of small molecules because of their advantages. In addition, through the incorporation of nanotechnologies, the detection property of each technique-based enzymatic nanobiosensors can be improved to measure harmful or important small molecules accurately. This review provides interdisciplinary information related to developing enzymatic nanobiosensors for small molecule detection, such as widely used enzymes, target small molecules, and electrochemical/fluorescence techniques. We expect that this review will provide a broad perspective and well-organized roadmap to develop novel electrochemical and fluorescent enzymatic nanobiosensors.

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Section: Enzymatic Fluorescent Nanobiosensorsmentioning

confidence: 99%

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Choi

Yoon

2023

Biosensors

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“…In this paper, a new fluorescence sensor system, which is composed of Europium (Eu3 +), is proposed to be used in the ALP assay of the human serum, which is a non-luminescence lanthanide metallic organic matrix (NO2-Eu-MOF NS). The fluorescent signal is switched on by an antenna ligand (PEPP), which competes with the Eu3 + ions of the nanometer-sheet, to generate emission species (Eux (PEPP) y (NO2BDC) z) in situ [4]. 4-Nitrophenylphosphate (PNPP), which is an ALP substrate, was hydrolysed to 4-nitrophenol.…”

Section: Fluorescent Biosensorsmentioning

confidence: 99%

Biomedical applications of fluorescent biosensors

Zhou

2023

TNS

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This study aims to systematically summarize the development history of fluorescent biosensors and their applications in biomedicine, and propose optimization strategies to promote the development of fluorescent biosensor technology according to the current challenges. This paper collects the literature of relevant research at home and abroad, and organizes and analyzes the basic principles, development history and biomedical applications of fluorescent biosensors. In addition, in view of the problems existing in fluorescent biosensors, some potential optimization strategies are proposed. After sorting out and analyzing the development history of fluorescent biosensors, it can be seen that the technology of fluorescent biosensors has made significant progress. In the field of biomedicine, fluorescent biosensors have been successfully applied to biomolecular detection, disease diagnosis and drug screening, showing great application potential. However, current fluorescent biosensors still face some challenges, such as light stability and sensitivity, which need to be further optimized. In summary, the application of fluorescent biosensors in biomedicine has broad prospects, but some technical challenges still need to be overcome.

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“…18,19 In Ln 3+ ions, Eu 3+ ions commonly emit visible red fluorescence through the naked eye under the illumination of ultraviolet light. 20–22 Eu MOFs have been employed for detection of analytes such as common nitro explosives, 23 anthrax biomarkers, 24 ALP, 25 and bromate, 26 but there has been relatively little coverage on the sequential detection of AA and AAO based on fluorescent Eu MOFs.…”

Section: Introductionmentioning

confidence: 99%

A facile fluorescence Eu MOF sensor for ascorbic acid and ascorbate oxidase detection

Dong,

Chen,

Kong

et al. 2024

Anal. Methods

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A new fluorescent biosensor based on inner filter effect and competitive coordination with the europium ion of non-luminescent Eu-MOF nanosheets for the determination of alkaline phosphatase activity in human serum

Cited by 18 publications

References 45 publications

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Biomedical applications of fluorescent biosensors

A facile fluorescence Eu MOF sensor for ascorbic acid and ascorbate oxidase detection

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