A New Fluoroalkyl Cyanoacrylate Surgical Adhesive

Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?

“…Evidence from our study showed that ethyl-2-cyanoacrylate-glued intestinal anastomosis provided satisfactory anastomotic healing without complications. We agree with Kirkegaard et al and others that [4,6,14,16,19] cyanoacrylate-glued intestinal anastomoses are as safe as sutured anastomoses under experimental conditions.…”

“…The present study showed that ATs in ethyl-2-cyanoacrylate subgroups were obviously shorter, which other investigators also observed [4,14,19]. This may certainly be an advantage in high-risk patients in whom the operative time should be minimized.…”

“…These latter moieties lacked histotoxicity and were found to be safe for in vivo applications [12,15,[20][21][22]. In our study, histotoxicity was not evaluated; but it is known from the previous studies that mild to moderate tissue reaction with mononuclear cell migration and giant cell formation that was similar to those observed by the use of polyglactin 910 sutures might have been present [14,19]. Nursal et al [23] reported severe inflammation using octyl cyanoacrylate in an experimental colonic anastomosis study and proposed that octyl cyanoacrylate seemed to be detrimental in the late phase of healing because of an ongoing intense inflammatory reaction.…”

“…Similarly, Kanellos et al and other investigators observed that omental adhesions and intestinal segments adhered around the anastomotic site in their experimental cyanoacrylate studies [6,14,19,27]. They stated that adhesion formation was more extensive in cyanoacrylate groups compared with sutured anastomoses [6,14,19,27]. Despite the positive effect on anastomotic strength in the early postoperative period, these adhesions might compromise intestinal passage after completion of inflammation process [27].…”

“…Cyanoacrylate is a vinyl monomer, which in the presence of weak base catalysts makes strong bonds with anionic polymerization [14,19]. Because histopathologic studies of cyanoacrylate-applied tissues revealed severe tissue reaction and inflammation, long-chain derivatives such as butyl cyanoacrylate and octyl cyanoacrylate were developed.…”