A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor

Valdenaire, Olivier; Giller, Thomas; Breu, Volker; Gottowik, J.; Kilpatrick, Gavin J.

doi:10.1016/s0167-4781(97)00047-x

Cited by 111 publications

(86 citation statements)

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“…3,4 Two different families of CRH receptors, CRH receptor type I (CRH-R1) and CRH receptor type II (CRH-R2), have been cloned from human tissue. [5][6][7][8][9] The R1 type presents greater selectivity for CRH, while the R2 receptor exhibits preferential selectivity for the CRH-like peptides, including urotensin and urocortin. In rodents, CRH-R1 are most abundant in neocortical, cerebellar, and sensory relay structures whereas CRH-R2 are predominantly localized in specific subcortical areas and peripheral tissues.…”

Section: Introductionmentioning

confidence: 99%

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

et al. 2001

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Corticotropin-releasing hormone (CRH) is a key neuroendocrine factor implementing endocrine, immune and behavioral responses to stress. CRH exerts its action through two major receptors, CRH-R1 and CRH-R2. Recently novel non-peptidic antagonists directed against CRH-R1 or CRH-R2 have been proposed as promising agents in the treatment of depression, anxiety and eating disorder. However, so far the CRH-receptor system has not been widely studied in humans. Therefore, we employed quantitative TaqMan PCR to analyze the expression and distribution of both CRH-R1 and CRH-R2 in human brain tissue and peripheral organs. Furthermore the expression of CRH receptors was analyzed for the first time in pituitaries of suicide victims by in situ hybridization and quantitative PCR. Our data demonstrated a different expression pattern in humans as compared to rodents. Both CRH-R1 and CRH-R2 were expressed in high amounts in the brain with the strongest expression in the pituitary. As described in rodents, however the CRH-R1 in human was the predominant receptor in the brain (82.7 ± 11.0%), whilst CRH-R2 was the predominant receptor in peripheral organs (77.0 ± 15.8%). There was a shift in the ratio of CRH-R1/R2 in the pituitaries of suicide victims. In conclusion, both CRH-R1 and CRH-R2 are widely expressed in human tissues with a distribution substantially different from rodents. Strong expression of both CRH-R1 and CRH-R2 in human pituitaries suggests that particularly under stress, activation of the HPA axis can be maintained through both receptors. Molecular Psychiatry (2001) 6, 540-546.

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Section: Introductionmentioning

confidence: 99%

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

et al. 2001

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“…The CRH 2α receptor is a 411 amino acid protein 21 and is 71% homologous to the CRH 1 receptor but has a different N-terminal sequence, 27 which is involved in the ligand-receptor interaction. 37 In humans CRH 2α is predominantly expressed in the hippocampus, heart, skeletal muscle, hypothalamus, septum and cortex. 37 CRH 2β is a 431 amino acid protein that differs from CRH 2α at the N terminus.…”

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confidence: 99%

“…37 In humans CRH 2α is predominantly expressed in the hippocampus, heart, skeletal muscle, hypothalamus, septum and cortex. 37 CRH 2β is a 431 amino acid protein that differs from CRH 2α at the N terminus. 21 It is found mainly in rat heart, lung and sketetal muscle aswell as having limited distribution in the septum, hippocampus and amygdala.…”

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confidence: 99%

The Prevention of Preterm Labour - Corticotropin Releasing Hormone Type 1 Receptors as a Target for Drug Design and Development

Keller¹,

Kirkwood

Morgan³

et al. 2003

MRMC

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The role of the corticotropin releasing hormone in the onset of labour and the subsequent medicinal chemistry implications of CRH antagonists for the prevention of premature birth, and identification of the CRH type 1 receptor as the target for this drug design, are reviewed here. Keywords AbstractThe role of the corticotropin releasing hormone in the onset of labour and the subsequent medicinal chemistry implications of CRH antagonists for the prevention of premature birth, and identification of the CRH type 1 receptor as the target for this drug design, are reviewed here.

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“…and 2γ and one truncation mutant (Valdenaire et al, 1997) ( Kostich et al, 1998) that differ in their N-termini due to alternative splicing. The splice variants have a common 377 amino acid C-terminal part, whereas the extreme N-termini, which are encoded by one or two exons (Dautzenberg and Hauger, 2002), differ substantially from one another.…”

Section: Crh Receptorsmentioning

confidence: 99%

“…The CRH 2α receptor, a 411-413 amino acid protein, has been isolated from mammalian and amphibian species (Dautzenberg et al, 1997) (Palchaudhuri et al, 1999). In contrast, CRH 2β receptors, which are 430-438 amino acids in size, have only been reported in mammals (Kishimoto et al, 1995) (Palchaudhuri et al, 1999) (Valdenaire et al, 1997). Finally, the 397 amino acid CRH 2γ receptor is exclusively found in humans (Kostich et al, 1998) (Palchaudhuri et al, 1999).…”

Section: Crh Receptorsmentioning

confidence: 99%

Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain – modelling central CRH system hyperactivity

Steiner²,

Engelholm³

et al. 2005

Pharmacopsychiatry

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A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor

Cited by 111 publications

References 11 publications

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

The Prevention of Preterm Labour - Corticotropin Releasing Hormone Type 1 Receptors as a Target for Drug Design and Development

Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain – modelling central CRH system hyperactivity

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