A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide

Lefer, David J.

doi:10.1073/pnas.0709010104

Cited by 318 publications

(184 citation statements)

References 19 publications

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“…Many of these studies focus on myocardial protection, and the cardioprotective effects of H 2 S have been demonstrated in cultured myocytes, isolated perfused hearts and in rodent and large animal models of coronary artery ligation and reperfusion. 9,11,13) Similarly, the intravenous injection of H 2 S (in the form of NaHS-a water soluble H 2 S donor) is also known to transiently decrease blood pressure in the rat. 19) In addition, physiologically relevant doses of H 2 S can promote angiogenesis via the activation of the Akt signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, H 2 S was identified as an important cell signaling molecule and plays a pivotal role in the cardiovascular and nervous system. [8][9][10] More evidences revealed that both endogenous and exogenous H 2 S exhibited the significant protective effects during a number of cardiovascular disease states. [11][12][13][14] In present work, we investigated the role of H 2 S in the regulation of HIF-1 activity under hypoxic condition in vascular smooth muscle cells (VSMCs).…”

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confidence: 99%

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Hypoxia-Inducible Factor-1.ALPHA. Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

Liu

Pan

Yang

et al. 2010

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Hypoxia-Inducible Factor-1.ALPHA. Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

Liu

Pan

Yang

et al. 2010

Biological & Pharmaceutical Bulletin

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“…Endogenous H 2 S is generated from L-cysteine catalyzed by cystathionine-γ-lyase (CSE) in the cardiovascular system. It has potential roles in many physiological processes and disease states in the human body and exerts regulatory effects on the pathogenesis of various cardiovascular diseases such as hypertension, pulmonary hypertension, shock and myocardial injury (4)(5)(6). A significant decrease in plasma H 2 S was observed in patients with coronary heart disease, and plasma H 2 S levels have been correlated with the severity of coronary heart disease (7).…”

Section: Introductionmentioning

confidence: 97%

Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty

Liang

Zhang

et al. 2012

Mol Med Report

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Abstract. Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H 2 S) plays potential roles in many physiological processes, such as vasodilatation and inhibition of smooth muscle cell proliferation. However, little is known regarding its role in arterial restenosis. In this study, we induced atherosclerotic-like lesions in rabbits, and we treated the rabbits with balloon angioplasty (BA) in a similar manner as PTA performed in the clinic. The rabbits were treated with sodium hydrosulfide (NaHS, a donor of H 2 S) or DL-propargylglycine (PPG, an inhibitor of H 2 S synthase). Treatment with NaHS significantly inhibited arterial restenosis following BA by reducing the intimal area and the intima/media ratio, while PPG treatment had a tendency to result in more severe restenosis. NaHS treatment significantly reduced smooth muscle cell (SMC) proliferation and elevated SMC apoptosis in the neointima. In contrast, PPG induced a significant increase in SMC proliferation. In conclusion, H 2 S attenuates the progression of neointimal hyperplasia and inhibits restenosis after BA. This discovery may lead to potential novel therapies, which can improve the prognosis of PAD patients.

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“…H ydrogen sulfide (H 2 S) has emerged as a new gaseous signaling molecule despite its reputation as a toxic gas with a repulsive odor (1). H 2 S is engaged in regulation and modulation of physiological functions such as vasorelaxation, vasodilatation, blood pressure modulation, and inhibition of apoptosis in a number of cell types (2)(3)(4)(5).…”

mentioning

confidence: 99%

No facilitator required for membrane transport of hydrogen sulfide

Mathai

Missner²,

Kügler

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

327

226

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Hydrogen sulfide (H2S) has emerged as a new and important member in the group of gaseous signaling molecules. However, the molecular transport mechanism has not yet been identified. Because of structural similarities with H 2O, it was hypothesized that aquaporins may facilitate H 2S transport across cell membranes. We tested this hypothesis by reconstituting the archeal aquaporin AfAQP from sulfide reducing bacteria Archaeoglobus fulgidus into planar membranes and by monitoring the resulting facilitation of osmotic water flow and H2S flux. To measure H2O and H2S fluxes, respectively, sodium ion dilution and buffer acidification by proton release (H 2S % H ؉ ؉ HS ؊ ) were recorded in the immediate membrane vicinity. Both sodium ion concentration and pH were measured by scanning ion-selective microelectrodes. A lower limit of lipid bilayer permeability to H 2S, P M,H 2 S > 0.5 ؎ 0.4 cm/s was calculated by numerically solving the complete system of differential reaction diffusion equations and fitting the theoretical pH distribution to experimental pH profiles. Even though reconstitution of AfAQP significantly increased water permeability through planar lipid bilayers, PM,H 2 S remained unchanged. These results indicate that lipid membranes may well act as a barrier to water transport although they do not oppose a significant resistance to H 2S diffusion. The fact that cholesterol and sphingomyelin reconstitution did not turn these membranes into an H2S barrier indicates that H 2S transport through epithelial barriers, endothelial barriers, and membrane rafts also occurs by simple diffusion and does not require facilitation by membrane channels. aquaporins ͉ gas transport ͉ membrane permeability ͉ unstirred layer ͉ signaling

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A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide

Cited by 318 publications

References 19 publications

Hypoxia-Inducible Factor-1.ALPHA. Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

Hypoxia-Inducible Factor-1.ALPHA. Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty

No facilitator required for membrane transport of hydrogen sulfide

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