A new high-resolution, high-throughput spectrometer: first experience as applied to Raman spectroscopy

Meade, Jeffrey T.; Behr, Bradford B.; Hajian, Arsen R.

doi:10.1117/12.919062

Cited by 13 publications

(4 citation statements)

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“…Besides lowering the excitation wavelength, the Raman signal intensity can be enhanced by increasing the laser power, increasing the interaction length between the laser and the sample by multiple-pass arrangements [70], or increasing the collected light through sample optics with reduced photon losses in the spectrometer [71].…”

Section: Raman Spectroscopymentioning

confidence: 99%

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

2020

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As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes.

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Section: Raman Spectroscopymentioning

confidence: 99%

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

2020

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“…Historically, efforts were been made to improve étendue 132 of instruments using image slicing. [133][134][135][136] A related concept, a pupil slicer, was developed and characterized recently 137,138 and is now applied to some commercial Raman instruments 139 and a portable Raman hyperspectral imaging instrument. 140 In portable Raman instruments, there has been a trend towards transmission gratings [141][142][143] (typically $f/1.3) and away from Czerny-Turner reflection designs (typically $f/3.5).…”

Section: Etendue Improvementmentioning

confidence: 99%

Portable Spectroscopy

Crocombe¹

2018

Appl Spectrosc

403

233

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Until very recently, handheld spectrometers were the domain of major analytical and security instrument companies, with turnkey analyzers using spectroscopic techniques from X-ray fluorescence (XRF) for elemental analysis (metals), to Raman, mid-infrared, and near-infrared (NIR) for molecular analysis (mostly organics). However, the past few years have seen rapid changes in this landscape with the introduction of handheld laser-induced breakdown spectroscopy (LIBS), smartphone spectroscopy focusing on medical diagnostics for low-resource areas, commercial engines that a variety of companies can build up into products, hyphenated or dual technology instruments, low-cost visible-shortwave NIR instruments selling directly to the public, and, most recently, portable hyperspectral imaging instruments. Successful handheld instruments are designed to give answers to non-scientist operators; therefore, their developers have put extensive resources into reliable identification algorithms, spectroscopic libraries or databases, and qualitative and quantitative calibrations. As spectroscopic instruments become smaller and lower cost, ''engines'' have emerged, leading to the possibility of being incorporated in consumer devices and smart appliances, part of the Internet of Things (IOT). This review outlines the technologies used in portable spectroscopy, discusses their applications, both qualitative and quantitative, and how instrument developers and vendors have approached giving actionable answers to non-scientists. It outlines concerns on crowdsourced data, especially for heterogeneous samples, and finally looks towards the future in areas like IOT, emerging technologies for instruments, and portable hyphenated and hyperspectral instruments.

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“…One approach is to utilize the optical-image slicer technology, which uses plane mirrors to divide a round image into narrow strips. A purely reflective based optical-pupil slicer has since been developed as a commercial product by tornado spectral systems, which is called the high throughput virtual slit (HTVS) [3,4]. The HTVS differs from image slicers in that it preserves the spatial information of the input aperture.…”

Section: Introductionmentioning

confidence: 99%

Avoiding the side-effect of high-performance spectrometers with coded apertures

Chi

Peng

et al. 2013

Appl. Opt.

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In this report, a high-resolution, high-signal-to-noise-coded aperture spectrometer is introduced that replaces the traditional single slit with two-dimensional array slits manufactured by microelectromechanic system technology. The encoding and decoding principle of this coded aperture spectrometer is described, as well as the instrument structure. We then discuss the side-effect, which is caused by sub-aperture manufacturing errors in size and position and the smear noise in the imaging CCD. The side-effect adversely affects the decoding wavelength accuracy of this spectrometer, so we present some effective ways to avoid this phenomenon and to increase the decoding wavelength accuracy of the spectrometer. In the end, we present our experimental results.

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A new high-resolution, high-throughput spectrometer: first experience as applied to Raman spectroscopy

Cited by 13 publications

References 0 publications

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

Portable Spectroscopy

Avoiding the side-effect of high-performance spectrometers with coded apertures

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