A new human genetic resource: a DNA bank established as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC)

Ring, Susan M.; Tyfield, Linda; Hamvas, Renata M. J.; Simmons, Hugh; Pembrey, Marcus; Golding, Jean; Team, Alspac Study

doi:10.1038/sj.ejhg.5200502

Cited by 91 publications

(69 citation statements)

References 5 publications

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“…Our aim in this study is to further investigate the relationship between the genetic variants in BDNF and BMI by genotyping the same genetic variants in BDNF in two sizable and well-characterized populations of British women: (1) the British Women's Heart and Health Study (BWHHS); and (2) the mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC). 10,11 Both studies have considerably greater statistical power than the original published study of this association, 9 and than a second published study that also reported a null association.…”

Section: Introductionmentioning

confidence: 88%

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

et al. 2009

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The goal of this study is to investigate the relationship between the Val66Met polymorphism in the brainderived neurotrophic factor (BDNF) and body mass index (BMI) in two sizable and well-characterized populations of British women: the British Women's Heart and Health Study (BWHHS) (age 60-79 years) and the mothers from the Avon Longitudinal Study of Parents and Children (age 16 -44 years). We genotyped the Val66Met polymorphism (rs6265) in these two populations, and conducted a linear regression analysis to test for an association between this polymorphism and BMI. Both study populations indicated an association between BMI and the Val66Met polymorphism, with individuals carrying the Met -Met genotype having a lower mean BMI than those with the Val -Met or Val -Val genotypes (in the BWHHS): mean BMI difference ¼ À0.911 kg/m 2 , 95% confidence interval (CI): À1.70 to À0.12, P ¼ 0.023; in the mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC): mean BMI difference ¼ À0.57 kg/m 2 , 95%CI: À1.08 to À0.054, P ¼ 0.03). In a pooled analysis of these two studies, together with one further published study that provided data in a suitable format for inclusion in our meta-analysis, we found a pooled difference of À0.76 (95% CI: À1.16, À0.036) for adult women; I 2 -test for heterogeneity ¼ 51%, P ¼ 0.13. Our study indicated an association between BDNF and BMI in two general population studies of women. The exact role of BDNF in weight regulation merits further investigation.

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Section: Introductionmentioning

confidence: 88%

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

et al. 2009

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“…There were 14,062 liveborn children. The study protocol has been described previously 43,44 and further details are on the ALSPAC website:…”

Section: Study Populationsmentioning

confidence: 99%

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

Weidinger

Baurecht

Wagenpfeil

et al. 2008

Journal of Allergy and Clinical Immunology

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“…One control series consisted of buccal scrape samples from children (n ¼ 64) and blood samples from their parents (n ¼ 128), recruited as part of the UK Childhood Cancer Study (2000) in the North West (NW) of England. The second control series consisted of blood samples from children (n ¼ 60) obtained as part of the Avon Longitudinal Study of Parents and Children (ALSPAC; Jones et al, 2000) and buccal samples from their parents (n ¼ 120; Ring et al, 2001). Sample collection and analyses were carried out with the approval of Local Research Ethics Committees.…”

Section: Case and Control Samplesmentioning

confidence: 99%

New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia

et al. 2007

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Gardner and co-workers advanced the hypothesis that the Seascale leukaemia cluster could have been caused by new mutations in germ cells, induced by paternal preconceptional irradiation (PPI) exposure at the Sellafield nuclear installation. Since evidence has shown that PPI can increase the de novo germline mutation rate in hypervariable minisatellite loci, we investigated the hypothesis that sporadic childhood leukaemia might be associated with an increased parental germline minisatellite mutation rate. To test this hypothesis, we compared de novo germline mutation rates in the hypervariable minisatellite locus, CEB1, in family trios (both parents and their child) of children with leukaemia (n ¼ 135) compared with unaffected control families (n ¼ 124). The majority of case and control germline mutations were paternal (94%); the mean paternal germline mutation rates of children with leukaemia (0.083) and control children (0.156) were not significantly different (odds ratio, 95% confidence interval: 0.50, 0.23 -1.08; P ¼ 0.11). There were no significant differences in case and control parental allele sizes, case and control germline mutation progenitor allele sizes (2.74 vs 2.54 kb; P ¼ 0.56), case and control mutant allele sizes (2.71 vs 2.67 kb; P ¼ 0.90), mutant allele size changes (0.13 vs 0.26 kb; P ¼ 0.10), or mutational spectra. Within the limitation of the number of families available for study, we conclude that childhood leukaemia is unlikely to be associated with increased germline minisatellite instability.

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A new human genetic resource: a DNA bank established as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC)

Cited by 91 publications

References 5 publications

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia

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