A New Hyperfractionation Effect in Thepharmacokinetics of Dopaminergic Agonist(cabergoline) for the Long-Term Treatment Ofnon-Functioning Pituitary Tumours

Burstein, Gabriel

doi:10.4183/aeb.2005.121

Cited by 1 publication

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“…The immediate merit of a mathematical system theoretic approach in neuroendocrinology is the revelation of a new typology and classification of dysfunctions/pathologies based on the feedback and feedforward circuitry as well as the revelation of sometimes new and even counter-intuitive drug therapies or therapeutic strategies to fix those dysfunctions (13,14,21,25,32).…”

Section: Introductionmentioning

confidence: 99%

Integrative System Theory of Hippocampal-Hypothalamic-Pituitary-Adrenal Axis for Cortisol Feedback Dysfunctions and Feedback Drug Therapies

Burstein¹

2012

Acta Endo (Buc)

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The stress driven cortisol dynamics of the Hippocampal-Hypothalamic-(Anterior) Pituitary-Adrenal (HHPA) axis with its negative feedback loops from the adrenals to pituitary and hypothalamus, in particular relation with hippocampus, have been the focus of the last few years boom of papers using various distinctive mathematical models, simulations, stability analyses and optimal control of these models. These many quantitative approaches led to discovering unknown connections between cortisol feedback loop dysfunctions and stress disorders (post-traumatic stress disorder (PTSD), depression, chronic fatigue syndrome (CFS)), adrenal suppression and atrophy, Alzheimer (AD) and hypocampal cognitive dysfunctions (memory loss) leading to new drug treatment strategies.We assemble here together and unify these results, including our own early work, in order to create an integrative mathematical system theory framework for HHPA & HPA and stress driven cortisol dynamics in which various clinical disorders appear as various quantifiable negative feedback loop dysfunctions and drug therapies correcting these disorders appear as feedback model based treatments: a neuroendocrine system theory for cortisol "feedback pathology" and its existing and future possible "feedback therapies".

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