A New Hypotensive Steroid Alkaloid From Conopharyngia Pachysiphon

Steroidal alkaloids are derived from the steroid skeleton with one or two nitrogen atoms. They are widely distributed in tropical and subtropical regions and possess a range of biological activities. The structures of steroidal alkaloids are comparable to those of anabolic steroids, steroidal hormones, and corticosteroids, making them a valuable source for drug discovery. Taxonomically, steroidal alkaloids are limited in distribution to certain plant families, predominantly the Apocynaceae, Buxaceae, Solanaceae, and Liliaceae. This review highlights the steroidal alkaloids from the Apocynaceae family and their biological activities. The articles published from 1919 to 2021 were included in this review. A total of 163 steroidal alkaloids and 12 biological activities were reported from plant species belonging to the Apocynaceae family in this period. Of the 410 genera in the Apocynaceae, only 10 contain steroidal alkaloids. Although some alkaloids from the Apocynaceae family were also reported in the Buxaceae family, especially tetracyclic triterpenes with a pregnane side chain, most steroidal alkaloids can only be found in several genera of the Apocynaceae family.

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“…pachysiphon Stapf), and deduced as 20α-amino-3,5-pregnadiene ( 158 ) and 20α-amino-3β-hydroxy-5-pregnene-β-D-glucoside ( 159 ). 136…”

Section: Distribution Of Steroidal Alkaloidsmentioning

confidence: 99%

“…Two pregnane-type steroidal alkaloids were isolated from the roots of Conopharyngia pachysiphon (synonym: T. pachysiphon Stapf), and deduced as 20αamino-3,5-pregnadiene (158) and 20α-amino-3β-hydroxy-5pregnene-β-D-glucoside (159). 136…”

Section: Tabernaemontana Speciesmentioning

confidence: 99%

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

Karim

Ismail

Osman

2022

Natural Product Communications

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“…2.2) are structurally steroid alkaloids. The hypotensive principle of Conopharyngia pachysiphon was elucidated as being 20-amino-3-f3-hydroxy-5-pregnene-f3-D-glucoside (DICKEL et al 1959) and therefore also belongs to the steroid alkaloids.…”

Section: Steroid Alkaloidsmentioning

confidence: 99%

Natural Agents and Extracts

Becker¹

1990

Pharmacology of Antihypertensive Therapeutics

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“…It appears to have little or no activity against the malaria parasite (Stephenson, 1948) or helminths (Janot and Cavier, 1949;Mackie and others, 1955) although it has been reported to show weak antituberculous properties (Lambin and Bernard, 1953;Meissner and Hesse, 1930). Its toxicity towards Entamoeba dysenteriae has led to a limited clinical use (see for example Acton and Chopra, 1933;Lavier, Crosnier and Merle, 1948;Tanguy, Robin and Raoult, 1948) particularly on the Indian subcontinent and there have been several studies (see for example Durieux, Trenous and Tanguy, 1948 ;Kaushiva, 1957;Muhlpfordt and Martinez-Silva, 1956 ;Piette, 1950) in which its efficacy has been compared to that of emetine. The results indicate that it is inferior to emetine as an amoebicide, but not such a potent emetic.…”

Section: VImentioning

confidence: 99%