A new <i>HLA‐A*26</i> family allele – <i>HLA‐A*26:103</i>

Street, J.; Climer, T.; Johnson, J.; Pepperall, J.; Darke, C.

doi:10.1111/tan.12551

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…It is exemplified from these and other studies (Cao et al ., ) that the serological reactivity of rare allele products, with monoclonal antibodies in particular (Street et al ., ), provides a useful and practical method of studying HLA‐class I and II epitopes.…”

Section: Resultsmentioning

confidence: 97%

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139

Street

Johnson

Lemin

et al. 2015

Int J Immunogenetics

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Three novel HLA-Class II alleles, DRB1*03:112, DQB1*03:02:16 and DQB1*03:139, are described with predicted bearing haplotypes of A*02:01, B*40:01, C*03:04, DRB1*03:112, DQB1*02:01; A*23:01, B*15:01, C*03:03, DRB1*04:01, DQB1*03:02:16 and A*01:01, B*44:02, C*05:01/03, DRB1*04:01, DQB1*03:139. Serological tests showed that the DRB1*03:112 and DQB1*03:139 specificities failed to react as expected with some well-documented monoclonal antibodies. Subsequent examination of published HLA-Class II epitopes and inspection of amino acid motifs suggested that epitopes exist that include the positions of their single substitutions (F31C between DRB1*03:01:01:01 and DRB1*03:112, and R48P between DQB1*03:01:01:01 and DQB1*03:139 specificities). This suggests that the reactivity of the monoclonal antibodies used was dependent on these epitopes and that their loss from these rare allele products resulted in their aberrant serology. The new alleles were found after the sequence-based typing of 32 530 random UK European routine blood donors suggesting that each has a maximum carriage frequency of 0.0031% in the blood donor population resident in Wales.

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Section: Resultsmentioning

confidence: 97%

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139

Street

Johnson

Lemin

et al. 2015

Int J Immunogenetics

Self Cite

View full text Add to dashboard Cite

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Nomenclature for factors of the HLA system, update April 2015

Marsh¹

2015

Human Immunology

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Nomenclature for factors of the HLA system, update April 2015

Marsh

2015

Int J Immunogenetics

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A new HLA‐A26* family allele – HLA‐A26:103*

Abstract: HLA-A26:103 differs from A26:01:01 by one base (559C>G) in exon 3 resulting in an amino acid substitution of R163G.

Cited by 4 publications

References 6 publications

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139

Nomenclature for factors of the HLA system, update April 2015

Nomenclature for factors of the HLA system, update April 2015

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A new HLA‐A*26 family allele – HLA‐A*26:103

Abstract: HLA-A*26:103 differs from A*26:01:01 by one base (559C>G) in exon 3 resulting in an amino acid substitution of R163G.

Cited by 4 publications

References 6 publications

Immunogenetics of three novel HLA‐Class II alleles: DRB1*03:112, DQB1*03:02:16 and DQB1*03:139

Immunogenetics of three novel HLA‐Class II alleles: DRB1*03:112, DQB1*03:02:16 and DQB1*03:139

Nomenclature for factors of the HLA system, update April 2015

Nomenclature for factors of the HLA system, update April 2015

Contact Info

Product

Resources

About

A new HLA‐A26* family allele – HLA‐A26:103*

Abstract: HLA-A26:103 differs from A26:01:01 by one base (559C>G) in exon 3 resulting in an amino acid substitution of R163G.

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139

Immunogenetics of three novel HLA‐Class II alleles: DRB103:112, DQB103:02:16 and DQB1*03:139