A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele

Koide, Tsuyoshi; Moriwaki, Kazuo; Uchida, Katsuhisa; Mita, Akihiko; Sagai, Tomoko; Yonekawa, Hiromichi; Katoh, Hideki; Miyashita, Nobumoto; Tsuchiya, Kimiyuk; Nielsen, Toennes J.; Shiroishi, Toshihiko

doi:10.1007/s003359900672

Mammalian Genome

1998

DOI: 10.1007/s003359900672

|View full text |Cite

A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele

Tsuyoshi Koide

Kazuo Moriwaki

Katsuhisa Uchida

et al.

Abstract: A new inbred strain JF1 (Japanese Fancy Mouse 1) was established from a strain of fancy mouse. Morphological and genetical analysis indicated that the mouse originated from the Japanese wild mouse, Mus musculus molossinus. JF1 has characteristic coat color, black spots on the white coat, with black eyes. The mutation appeared to be linked to an old mutation piebald (s). Characterization of the causative gene for piebald, endothelin receptor type B (ednrb), demonstrated that the allele in JF1 is same as that of… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1998

2012

Publication Types

Select...

Article9

Relationship

Self Cite0

Independent9

Authors

Journals

Cited by 109 publications

(99 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…JF1 mice show irregular black spots on the white coat, which resembles the classic piebald (s/s) mutation described in 1920 in the U.S.A. [4]. Genetic analysis employing microsatellite markers used for typing mouse subspecies led to the conclusion that JF1 is of the Asian species Mus musculus molossinus [9]. Further, the same haplotype patterns in single nucleotide polymorphisms of Ednrb were shown in JF1 and s/s strains, so they were thought to be derived from the same Asian fancy mice.…”

mentioning

confidence: 94%

“…The s locus on mouse chromosome 14 encodes Ednrb, a G protein-coupled, seven-transmembrane domain receptor that recognizes a family of small peptides known as endothelins [7]. Japanese Fancy Mouse 1 (JF1), an inbred strain established at the National Institute of Genetics in Japan was purchased from a market in Denmark in 1987 [9]. JF1 mice show irregular black spots on the white coat, which resembles the classic piebald (s/s) mutation described in 1920 in the U.S.A. [4].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

et al. 2012

View full text Add to dashboard Cite

ABSTRACT. The Japanese Fancy Mouse 1 (JF1) has a characteristic coat color similar to a very old mutant, piebald. The mutation in JF1 and the classic piebald was previously thought to be the same recessive allele in the endothelin B receptor gene (Ednrb) according to the haplotype pattern, which is insufficient for this conclusion. In this study, we identified the same insertion of a retroposon-like element in intron 1 of the Ednrb gene in JF1 as in the classic piebald mutation by PCR. Further, we investigated whether the intestine shows neuronal intestinal malformations such as hypoganglionosis and immaturity of ganglion cells by histochemical staining. Though it has been assumed that the defect of neural crest-derived lineages is restricted to melanocytes in JF1, we found that the enteric innervation and neuronal density were impaired throughout the whole colon in JF1 mice.

show abstract

mentioning

confidence: 94%

mentioning

confidence: 99%

Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

et al. 2012

View full text Add to dashboard Cite

show abstract

“…These subspecies were separated about one million years ago and about 1% of their genome sequences are different. [3][4][5][6][7][8] Therefore, strains MSM/Ms 9 and Japanese Fancy Mouse 1 (JF1), 10 which were established from M.m. molossinus, are powerful genetic resources to analyze disease processes.…”

mentioning

confidence: 99%

Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression

Wang

Ohmuraya

Suyama

et al. 2010

Laboratory Investigation

View full text Add to dashboard Cite

To analyze susceptibility to acute pancreatitis, five mouse strains including Japanese Fancy Mouse 1 (JF1), C57BL/6J, BALB/c, CBA/J, and C3H/HeJ were treated with either a cholecystokinin analog, cerulein, or a choline-deficient, ethioninesupplemented (CDE) diet. The severity of acute pancreatitis induced by cerulein was highest in C3H/HeJ and CBA/J, moderate in BALB/c, and mildest in C57BL/6J and JF1. Basal protein expression levels of the serine protease inhibitor, Kazal type 3 (Spink3) were higher in JF1 and C57BL/6J mice than those of the other three strains under normal feeding conditions. After treatment with cerulein, expression level of Spink3 increased remarkably in JF1 and mildly in C57BL/6J, BALB/c, CBA/J, and C3H/HeJ strains. Increased proteinase, serine, 1 (Prss1) protein expression accompanied by increased trypsin activity with cerulein treatment was observed in susceptible strains such as CBA/J and C3H/HeJ. Similar results were obtained with a CDE diet. In the 3 kb Spink3 promoter region, 92 or 8 nucleotide changes were found in JF1 or C3H vs C57BL/6J, respectively, whereas in the Prss1 promoter region 39 or 46 nucleotide changes were found in JF1 or C3H vs C57BL/6J, respectively. These results suggest that regulation of Prss1 and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis. The JF1 strain, which is derived from the Japanese wild mouse, will be useful to examine new mechanisms that may not be found in other laboratory mouse strains. Over 450 inbred strains of mice have been described, 1 providing a wealth of different genotypes and phenotypes for studying human diseases. Actually, the use of various breeding strategies in combination with positional cloning and positional candidate gene approach has led to the discovery of many genes that underlie human disease. 2 The Japanese wild mouse, belonging to Mus musculus molossinus, has several genetic characteristics clearly distinguishable from the European wild mouse, derived from M.m. domesticus. These subspecies were separated about one million years ago and about 1% of their genome sequences are different. [3][4][5][6][7][8] Therefore, strains MSM/Ms 9 and Japanese Fancy Mouse 1 (JF1), 10 which were established from M.m. molossinus, are powerful genetic resources to analyze disease processes.Many inbred strains have been bred for specific phenotypes. C57BL/6J mice are susceptible to high-fat diet-induced type II diabetes. 11 JF1 mice are especially sensitive to high-fat diet-induced diabetes and obesity, whereas MSM/Ms mice are resistant. 12 To date, however, there is little information about the difference in severity of pancreatitis among inbred strains of mice.Acute pancreatitis is an important disease that can be triggered by a variety of factors, including excessive alcohol consumption, 13-16 obstruction of the ampulla of Vater by gall stones, 17,18 and genetic factors. 19,20 Hereditary chronic pancreatitis is a rare form of early onset chronic pancreatitis, characterized by the onset of recurrent...

show abstract

“…The JF1 strain of M. m. molossinus was derived from fancy mice and established as a strain at the National Institute of Genetics, Mishima, Japan [8]. Three wild mouse strains of M. m. musculus were derived from Okha, Irkutsk and Novokachalinsk in Russia and established by one of authors (T. K.) as inbred strains Okh/TUA, Irk/TUA and Nov/TUA, respectively.…”

mentioning

confidence: 99%

Mapping of rRNA Gene Loci in the Mice, Mus musculus molossinus (Japan) and Mus musculus musculus (Russia) by Double Color FISH

Ito

Tsuchiya²,

Osawa

et al. 2008

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Ribosomal RNA gene (rDNA) loci of Russian Mus musculus musculus and of Japanese Mus musuculus molossinus were mapped by double color FISH. The total number of rDNA loci was varied from 5 to 12, although the loci on chromosomes 12, 15, 16, 18, and 19 were common to all mice examined. Instead, polymorphisms of the rDNA loci were found on chromosomes 1, 5, 8, 9, 10, 11, 13 and 17 [4,14]. The karyotype of these subspecies is identical except for the difference in sizes of the Y chromosome [10]. In the laboratory strains, the total number of rDNA loci varied from three to five, and the loci were limited to chromosomes 12, 15, 16, 18 and 19 [1, 3, 5, 9]. Although the locus polymorphism was found on chromosomes 12, 15, 16 and 19, rDNA locus on the chromosome 18 was observed consistently in all laboratory strains examined. Such variations of rDNA loci on these chromosomes were reported in the wild mice of Mus musculus species, as well as the polymorphism of rDNA loci on other chromosomes [11,13].The evolution of rDNA has been the subject of controversy for many years, as the clusters of rDNA at different chromosomal loci retain the strict sequence homology and the copy number of the gene varied about one to several hundred in mammals [12]. Mus musculus species is a good model system for the analysis of rDNA evolution, because of the remarkable variation of rDNA loci not only between different subspecies but also within the same subspecies. In the present study, to elucidate the evolution of rDNA loci in Mus musculus, we further determined rDNA loci in wild and wild mouse-derived strains of M. m. molossinus and wild mouse-derived strains of M. m. musculus.A wild M. m. molossinus was captured in Machida, Tokyo, Japan. The JF1 strain of M. m. molossinus was derived from fancy mice and established as a strain at the National Institute of Genetics, Mishima, Japan [8]. Three wild mouse strains of M. m. musculus were derived from Okha, Irkutsk and Novokachalinsk in Russia and established by one of authors (T. K.) as inbred strains Okh/TUA, Irk/TUA and Nov/TUA, respectively. Lymphocytes, isolated from the spleen, were cultured, and air-dried chromosome slides were prepared following the protocol of Matsuda et al. [11].A human 28S-rDNA (pHr14E3, Human Science Research Resource Bank, Japan) was labeled by nick translation with digoxigenin-11-dUTP and ethanol-precipitated with salmon sperm DNA and tRNA. This probe DNA was dissolved in 8 µl of 100% formamide and denatured at 75°C for 10 min. Biotin-labeled mouse chromosome paints (Cambio, Cambridge, UK) were denatured following the manufacturer's protocol. The labeled probes, which consist of 8 µl of rDNA and 3 µl of chromosome paints, were mixed with 11 µl of hybridization buffer (10 × SSC, 1 mg/ml BSA and 50% dextran sulfate). Prior to hybridization, the slides were treated with RNase (100 µg/ml in 2 × SSC) for 1 hr to remove the cellular rRNA. The slides were washed in 2 × SSC, dehydrated in an ethanol series, denatured at 70°C for 2 min in 70% formamide in 2 × SSC...

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele

Cited by 109 publications

References 14 publications

Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression

Mapping of rRNA Gene Loci in the Mice, Mus musculus molossinus (Japan) and Mus musculus musculus (Russia) by Double Color FISH

Contact Info

Product

Resources

About