A New Inflammation Marker in Rheumatoid Arthritis: Immature Granulocyte

Abstract

Objective: This study aimed to reveal whether immature granulocyte levels can be used for determining the disease activity of rheumatoid arthritis.
 
 Material and Methods: The study was conducted in the Kastamonu Rehabilitation Center. The data of 163 patients with rheumatoid arthritis were reviewed retrospectively. Laboratory data of 92 healthy individuals were used for the control group. Complete blood cell counts, measurement of erythrocyte sedimentation rate, and C-reactive protein level were used for the laboratory assessments. The individuals with active infection and any hematological, cardiovascular, metabolic disorder, malignancy, history of trauma, surgery, and hospitalization within the last 15 days were excluded from the study.
 
 Results: We found that the number and percentage of immature granulocyte were significantly higher in the patient group (p

Relationship of immature granulocytes with disease activity in rheumatoid arthritis

“…In this study, similar to the study reported by Özcan et al., 27 it was found that the number of IG and IG% were higher in RA patients than in healthy controls, and there was a positive relationship between IG, ESR, and CRP. Unlike that study, 27 it was found that IG# and IG% were independent diagnostic determinants of RA. In this study, disease activity was determined by DAS28.…”

“…It was stated that DAS28 and also other RA disease activity indexes (CDAI, and SDAI) were not evaluated in the study and that studies evaluating the relationship between DAS28 and IGs are needed 27 . In this study, similar to the study reported by Özcan et al., 27 it was found that the number of IG and IG% were higher in RA patients than in healthy controls, and there was a positive relationship between IG, ESR, and CRP. Unlike that study, 27 it was found that IG# and IG% were independent diagnostic determinants of RA.…”

“…As a result of the study, it was stated that the IG level is a marker of inflammation in RA but the IG level was not sensitive and specific for RA 27 . It was stated that DAS28 and also other RA disease activity indexes (CDAI, and SDAI) were not evaluated in the study and that studies evaluating the relationship between DAS28 and IGs are needed 27 . In this study, similar to the study reported by Özcan et al., 27 it was found that the number of IG and IG% were higher in RA patients than in healthy controls, and there was a positive relationship between IG, ESR, and CRP.…”

“…In a very recent study evaluating IG in RA and healthy control and the relationship between IGs and ESR and CRP, it was reported that the number of IG and IG% were high in patients with RA and that there was a positive relationship between IG and ESR and CRP 27 . As a result of the study, it was stated that the IG level is a marker of inflammation in RA but the IG level was not sensitive and specific for RA 27 . It was stated that DAS28 and also other RA disease activity indexes (CDAI, and SDAI) were not evaluated in the study and that studies evaluating the relationship between DAS28 and IGs are needed 27 .…”

“…It has been shown that increased IG % is a useful and accurate indicator for determining the severity of acute cholecystitis 26 . In a very recent study evaluating IG in RA and healthy control and the relationship between IGs and ESR and CRP, it was reported that the number of IG and IG% were high in patients with RA and that there was a positive relationship between IG and ESR and CRP 27 . As a result of the study, it was stated that the IG level is a marker of inflammation in RA but the IG level was not sensitive and specific for RA 27 .…”