A New Inflammatory Marker for Bone Loss and Low Bone Mineral Density: Platelet-Tolymphocyte Ratio

Köseoğlu, Sezen Bozkurt

doi:10.2217/bmm-2016-0188

Cited by 30 publications

(32 citation statements)

References 32 publications

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“…In our study, there was no significant relationship between low BMD and NLR in patients with hemophilia. Koseoglu et al [21] reported that PLR in postmenopausal women might be predictive of low BMD [21]. In this study, although the PLR was higher in hemophilic patients compared to controls, this result was not statistically significant.…”

Section: Discussioncontrasting

confidence: 61%

“…We found no significant differences in CBC, ESR, CRP, liver and renal functions, ALP, Alb, P, total bilirubin, and fasting blood glucose between the two groups. A few studies reported an association of NLR, PLR, and MPV with osteoporosis [19][20][21][22]. However, no previous study evaluated the association between low BMD and NLR, PLR and MPV in hemophiliacs.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, several recent studies have found a significant association between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV), with low BMD [19][20][21][22]. However, this association has not been evaluated in hemophilic patients.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

Dağlı

Kutlucan

Abuşoğlu

et al. 2018

Bosn J of Basic Med Sci

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A decrease in bone mass is observed in hemophilic patients. The aim of this study was to evaluate bone mineral density (BMD), parathyroid hormone (PTH), 25-hydroxy vitamin D (vitamin D), and a bone formation and resorption marker, procollagen type I N-terminal propeptide (PINP) and urinary N-terminal telopeptide (uNTX) respectively, in hemophilic patients and healthy controls. Laboratory parameters related to the pathogenesis of bone loss such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were also evaluated. Thirty-five men over 18 years of age, with severe hemophilia (A and B) and receiving secondary prophylaxis, were included in the study. The same number of age-, sex-, and ethnicity-matched healthy controls were evaluated. Anthropometric, biochemical, and hormonal parameters were determined in both groups. No significant difference in anthropometric parameters was found between the two groups. The BMD was low in 34% of hemophilic patients. Vitamin D, calcium, and free testosterone levels were significantly lower (p < 0.001, p = 0.011, p < 0.001, respectively), while PTH, PINP, and activated partial thromboplastin time (aPTT) levels were significantly higher (p < 0.014, p = 0.043, p < 0.001, respectively), in hemophilic patients compared to controls. There was no significant difference between the two groups in NLR, PLR, phosphorus, thyroid-stimulating hormone, and uNTX level. The reduction of bone mass in hemophilic patients may be evaluated using the markers of bone formation and resorption, enabling early detection and timely treatment.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

Dağlı

Kutlucan

Abuşoğlu

et al. 2018

Bosn J of Basic Med Sci

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“…Finally, in a cohort of postmenopausal women (N=211), PLR, but not platelet count or NLR, was significantly elevated in women with low bone mineral density (BMD) than in women with normal BMD ( P <0.05); PLR was also negatively correlated with femoral BMD (r=−0.21, P <0.002) [52]. A potential mechanism of the association between PLR and bone loss may be related to persistent systemic inflammation with impaired calcium transport and vitamin D metabolism, leading to osteoporosis and bone fractures [52]. Clinical implications of such a mechanism in postmenopausal women with and without chronic inflammatory diseases remain to be elucidated in specifically designed prospective studies.…”

Section: Plr In Neoplastic Prothrombotic and Metabolic Diseasesmentioning

confidence: 99%

The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases

et al. 2019

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The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios. Several large observational studies have demonstrated the value of shifts in PLR in evaluating the severity of systemic inflammation and predicting infections and other comorbidities, in inflammatory rheumatic diseases. The value of PLR as an inflammatory marker increases when its fluctuations are interpreted along with other complementary hematologic indices, particularly the neutrophil-to-lymphocyte ratio (NLR), which provides additional information about the disease activity, presence of neutrophilic inflammation, infectious complications, and severe organ damage in systemic lupus erythematosus. PLR and NLR have high predictive value in rheumatic diseases with predominantly neutrophilic inflammation (e.g., Behçet disease and familial Mediterranean fever). High PLR, along with elevated platelet count, is potentially useful in diagnosing some systemic vasculitides, particularly giant-cell arteritis. A few longitudinal studies on rheumatic diseases have demonstrated a decrease in PLR in response to anti-inflammatory therapies. The main limitations of PLR studies are preanalytical faults, inadequate standardization of laboratory measurements, and inappropriate subject selection. Nonetheless, accumulating evidence suggests that PLR can provide valuable information to clinicians who encounter multisystem manifestations of rheumatic diseases, which are reflected in shifts in platelet, lymphocyte, neutrophil, or monocyte counts. Interpretation of PLR combined with complementary hematologic indices is advisable to more accurately diagnose inflammatory rheumatic diseases and predict related comorbidities.

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“…The lower expression of the receptor also induced a worst response to vitamin D and a consequent increase in PTH levels [45]. In addition, evaluating postmenopausal OP patients, the PLT/lymphocyte ratio was found to correlate with low BMD [33,48], in particular in reference to the femoral and lumbar district [48], which is also related to low vitamin D levels, supporting the hypothesis that inflammation correlates with vitamin D levels [48]. The relationship between peripheral blood cell count and BMD in OP was investigated also by Kim et al which observed that PLTs count, as well as white and red blood cells counts, correlate with BMD in OP patients [43].…”

Section: Platelet Functions/features and Growth Factor In Plts In Ostmentioning

confidence: 99%

Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence

Salamanna

Maglio

Sartori

et al. 2020

IJMS

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Background: With the increase in aging population, the rising prevalence of osteoporosis (OP) has become an important medical issue. Accumulating evidence showed a close relationship between OP and hematopoiesis and emerging proofs revealed that platelets (PLTs), unique blood elements, rich in growth factors (GFs), play a critical role in bone remodeling. The aim of this review was to evaluate how PLT features, size, volume, bioactive GFs released, existing GFs in PLTs and PLT derivatives change and behave during OP. Methods: A systematic search was carried out in PubMed, Scopus, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases to identify preclinical and clinical studies in the last 10 years on PLT function/features and growth factor in PLTs and on PLT derivatives during OP. The methodological quality of included studies was assessed by QUIPS tool for assessing risk of bias in the clinical studies and by the SYRCLE tool for assessing risk of bias in animal studies. Results: In the initial search, 2761 studies were obtained, only 47 articles were submitted to complete reading, and 23 articles were selected for the analysis, 13 on PLT function/features and growth factor in PLTs and 10 on PLT derivatives. Risk of bias of almost all animal studies was high, while the in the clinical studies risk of bias was prevalently moderate/low for the most of the studies. The majority of the evaluated studies highlighted a positive correlation between PLT size/volume and bone mineralization and an improvement in bone regeneration ability by using PLTs bioactive GFs and PLT derivatives. Conclusions: The application of PLT features as OP markers and of PLT-derived compounds as therapeutic approach to promote bone healing during OP need to be further confirmed to provide clear evidence for the real efficacy of these interventions and to contribute to the clinical translation.

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A New Inflammatory Marker for Bone Loss and Low Bone Mineral Density: Platelet-Tolymphocyte Ratio

Abstract: PLR level may predict low BMD with baseline measurement in postmenopausal women.

Cited by 30 publications

References 32 publications

Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases

Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence

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