A new insight of cadmium-induced cellular evidence of autophagic-associated spermiophagy during spermatogenesis

Ali, Waseem; Deng, Kai; Sun, Jian; Ma, Yonggang; Liu, Zongping; Zou, Hui

doi:10.1007/s11356-023-29548-9

Cited by 8 publications

(4 citation statements)

References 55 publications

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“…Autophagy has a role in cellular remodeling, energy balancing, and environmental cue response in the male reproductive tract, which includes the testes and epididymis [9,10]. The dynamic nature of autophagy enables cells to adapt to changing environments, ensuring optimal function even in stressful situations.…”

Section: Introductionmentioning

confidence: 99%

Potential role of autophagy in the male reproductive system

Muhammad Azhar,

Chandar,

Abdul Salam

et al. 2024

Int J Sex Reprod Health Care

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Autophagy is a highly controlled cellular mechanism that maintains cellular homeostasis by degrading and recycling cellular components. In recent years, there has been a greater concentration on understanding the role of autophagy in the male reproductive system. This review addresses the potential importance of autophagy in many aspects of male reproductive physiology, such as spermatogenesis, sperm maturation, and testicular function. The role of autophagy in male fertility, sperm quality, and response to environmental stressors is explored. Insights into the molecular mechanisms driving autophagy in male reproductive cells cover the groundwork for future research targeted at understanding the complex relationship between autophagy and male reproductive health.

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Section: Introductionmentioning

confidence: 99%

Potential role of autophagy in the male reproductive system

Muhammad Azhar,

Chandar,

Abdul Salam

et al. 2024

Int J Sex Reprod Health Care

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“…The process of spermatogenesis involves multiple steps involving SSCs that simultaneously undergo self-renewal and differentiation and then undergo sequential cell-fate transitions between mitosis and meiosis to produce highly specialized sperms [2]. The process of spermatogenesis also involves spermiogenesis (a spermatogenesis is the metamorphosis of spermatogonia into spermatozoa and includes all functional and structural changes that occur throughout this process) [3,4]. During the course of spermatogenesis, cells undergo a number of stages where they progress from spermatogonia to mature sperm [5].…”

Section: Introductionmentioning

confidence: 99%

An overview of novel transcription factors involved in spermatogonial stem cells

Hasani Mahforoozmahalleh,

Azizi

2024

Obstetrics and Gynecology

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A unique subset of spermatogonial stem cells (SSCs) initiates and maintains spermatogenesis. These SSCs have unique morphological traits attached to the seminiferous tubules basement membrane. They provide the groundwork for a healthy stem cell system in the testis, which is essential for spermatogenesis and other reproductive functions. The fascinating proteins known as transcription factors (TFs) have a great deal of control over gene expression in all living things. Some TFs are essential to the coordination of the complex dance known as spermatogenesis. Certain mutations in TFs may lead to the disorder of spermatogenesis. Distinguishing these TFs will be helpful to understand spermatogenesis and to locate possible therapeutic targets. In this chapter, we will review the recently identified TFs including E4F1, FoxP4, A-MYB, TCFL5, and TCF3 that play a role in SSCs. Enrich Shiny gene ontology and Cytoscape tools were used to predict the molecular connections and functional characteristics of proteins in order to find the key pathways. Our bioinformatic analysis will help us to understand these new and important connections between the TFs and the remaining gene expression in the protein network.

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“…Cadmium is one of the heavy metals which is a different type of pollutant having a 20-40 years half-life which leads to storage in the body for a longer period of time Ali, Deng, et al, 2023;Takiguchi & Yoshihara, 2006). It acts as an endocrine disrupter and may affect the function and development of the endocrine system of a human.…”

Section: Introductionmentioning

confidence: 99%

“…There are various industrial and environmental sources by which humans can come in contact with heavy metals, which are hazardous to the endocrine system (Wu et al, 2017). Cadmium is one of the heavy metals which is a different type of pollutant having a 20–40 years half‐life which leads to storage in the body for a longer period of time (Ali, Bian, Ali, et al, 2023; Ali, Deng, et al, 2023; Takiguchi & Yoshihara, 2006). It acts as an endocrine disrupter and may affect the function and development of the endocrine system of a human.…”

Section: Introductionmentioning

confidence: 99%

Effect of cadmium on the regulatory mechanism of steroidogenic pathway of Leydig cells during spermatogenesis

Ji,

Fan,

Kakar

et al. 2023

J Exp Zool Pt A

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Cadmium is a male reproductive toxicant that interacts with a variety of pathogenetic mechanisms. However, the effect of cadmium on the regulatory mechanism of the steroidogenic pathway of Leydig cells during spermatogenesis is still ambiguous. Light microscopy, Western blot, immunohistochemistry, immunofluorescence, and quantitative polymerase chain reaction were performed to study the regulatory mechanism of the steroidogenic pathway of Leydig cells during spermatogenesis. The results indicated that in the control group, Leydig cells showed dynamic immunoreactivity and immunosignaling action with a strong positive significant secretion of 3β‐hydroxysteroid hydrogenase (3β‐HSD) in the interstitial compartment of the testis. Leydig cells showed a high active regulator mechanism of the steroidogenic pathway with increased the proteins and genes expression level of steroidogenic acute regulatory protein (STAR), cytochrome P450 cholesterol (CYP11A1), cytochrome P450 cholesterol (CYP17A1), 3β‐hydroxysteroid hydrogenase (3β‐HSD) 17β‐hydroxysteroid hydrogenase (17β‐HSD), and androgen receptor (AR) that maintained the healthy and vigorous progressive motile spermatozoa. However, on treatment with cadmium, Leydig cells were irregularly dispersed in the interstitial compartment of the testis. Leydig cells showed reduced immunoreactivity and immunosignaling of 3β‐HSD protein. Meanwhile, cadmium impaired the regulatory mechanism of the steroidogenic process of the Leydig cells with reduced protein and gene expression levels of STAR, CYP11A1, CYP17A1, 3β‐HSD, 17β‐HSD, and AR in the testis. Additionally, treatment with cadmium impaired the serum LH, FSH, and testosterone levels in blood as compared to control. This study explores the hazardous effect of cadmium on the regulatory mechanism of the steroidogenic pathway of Leydig cells during spermatogenesis.

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A new insight of cadmium-induced cellular evidence of autophagic-associated spermiophagy during spermatogenesis

Cited by 8 publications

References 55 publications

Potential role of autophagy in the male reproductive system

Potential role of autophagy in the male reproductive system

An overview of novel transcription factors involved in spermatogonial stem cells

Effect of cadmium on the regulatory mechanism of steroidogenic pathway of Leydig cells during spermatogenesis

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