A new isoflavone glycoside from flowers of<i>Pueraria Montana</i>var.<i>lobata</i>(Willd.) Sanjappa &amp; Pradeep

Ma, Yong; Shang, Ya‐Fang; Zhong, Zhifeng; Zhang, Yingshuo; Yang, Yang; Feng, Jun; Wei, Zhao‐Jun

doi:10.1080/14786419.2019.1655021

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…The nutritional quality of plants mainly depends on their primary metabolites, such as amino acids, nucleotides, polysaccharides, lipids, and vitamins, whereas secondary metabolites contain physiologically active substances that can have a great impact on human health [14][15][16]. All species in the Pueraria genus contain different contents of bioactive flavonoid and isoflavone, including kaempferol, acacetin, puerarin, daidzein, and genistein, which have radical scavenging functions and exhibit many pharmacological properties [17][18][19]. In recent years, the research on Pueraria has mainly focused on the differences in starch, mineral elements, and some specific secondary metabolites such as puerarin [10,20].…”

Section: Introductionmentioning

confidence: 99%

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

et al. 2021

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Pueraria lobata and its variety P. lobata var. thomsonii are both traditional Chinese medicines that have high nutritional and medical value; whereas another variety, P. lobata var. montana has low nutritional and medicinal value and can cause ecological disasters. The material basis of different nutritional and medicinal values, which are caused by metabolite differences among these varieties, remains to be further clarified. Here, we performed ultra performance liquid chromatography-tandem mass spectrometry based widely targeted metabolome analysis on Pueraria lobata, P. lobata var. thomsonii, and P. lobata var. montana. Among them, a total of 614 metabolites were identified, and distinguished from each other using orthogonal partial least squares discriminant analysis. Our results suggest that the nutritional differences between P. lobata and its varieties can be explained by variations in the abundance of amino acids, nucleotides, saccharides, and lipids; differences in flavonoids, isoflavones, phenolic acids, organic acids, and coumarins contents caused the differences in the medicinal quality of P. lobata and its varieties. Additionally, the key metabolites responsible for the classification of the three Pueraria varieties were identified. This study provides new insights into the underlying metabolic causes of nutritional and medicinal variation in P. lobata and its varieties.

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Section: Introductionmentioning

confidence: 99%

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

et al. 2021

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“…45 The C-4 of SIN is connected to the hydroxyl group, and the hydroxyl group, as an electron donor, can interact with radicals in the body to prevent oxidation. Compounds such as VC (IC 50 = 21 μg/mL 46 ) and resveratrol (IC 50 = 12.8 μg/mL 47 ) have more hydroxy groups, so they have stronger antioxidant activity than SIN. Natural phospholipids, such as soybean lecithin, can produce certain antioxidant effects under proper conditions.…”

Section: Discussionmentioning

confidence: 99%

In vitro and Ex vivo Antioxidant Activity and Sustained Release Properties of Sinomenine-Loaded Liposomes-in-Hydrogel Biomaterials Simulating Cells-in-Extracellular Matrix

Yang

Xia

et al. 2022

Natural Product Communications

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Sinomenine (SIN), a natural product, has been used to treat rheumatoid arthritis (RA) in China for thousands of years. SIN has been developed for the treatment of RA by way of tablets and injections, but both dosage forms have been associated with severe adverse reactions. Making SIN into liposomes-in-hydrogel biomaterials for external use has a good slow-release effect and can play an important role in avoiding the first-pass effect, gastrointestinal reaction, and increasing the local action time of drugs. SIN-loaded liposomes were formed by the thin-film dispersion method, then SIN-loaded liposomes-in-hydrogels were prepared by combining the SIN-L with hyaluronic acid (HA) hydrogels. In this paper, the basic characteristics, In vitro and Ex vivo release, and antioxidant activity of SIN-loaded liposomes-in-hydrogels were studied. The results showed that SIN-loaded liposomes-in-hydrogels have good sustained-release and antioxidant effects, and the preparation is expected to be a good biomaterial.

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“…A volume of 300 µL was added to a new centrifuge tube. (6) The sample was finally centrifuged for 3 min at 12,000 rpm at 4 • C and the supernatant was collected for analysis.…”

Section: Extraction Of Insect Tea Metabolitesmentioning

confidence: 99%

“…)), excrete feces, and are made through a series of processing processes [4]. Compared with ordinary tea, the components of insect tea have higher nutritional value and stronger antioxidant effects [5][6][7]. Insect tea contains amino acids, proteins, polyphenols, flavonoids, and other active ingredients; these components have health and medicinal functions.…”

Section: Introductionmentioning

confidence: 99%

Identification of Nutritional Ingredients and Medicinal Components of Hawk Tea and Insect Tea Using Widely Targeted Secondary Metabolomics

et al. 2023

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In this study, the metabolites in insect tea and hawk tea were analyzed by ultra-high performance liquid chromatography–triple quadrupole mass spectrometry. We found 49 metabolites in insect tea and hawk tea that can be used as key active components in traditional Chinese medicine, as well as 98 metabolites that can be used as active components of pharmaceutical preparations for the treatment of cancers, hypertension, cardiovascular diseases, etc. Comparative analysis found that insect tea and hawk tea had significant differences in their metabolic profiles. Insect tea contains more metabolites beneficial to human health than hawk tea; insect tea also has higher antioxidant activity in vitro than hawk tea. The results of this study will contribute to the development of new health foods using insect tea.

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A new isoflavone glycoside from flowers ofPueraria Montanavar.lobata(Willd.) Sanjappa & Pradeep

Cited by 9 publications

References 23 publications

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

In vitro and Ex vivo Antioxidant Activity and Sustained Release Properties of Sinomenine-Loaded Liposomes-in-Hydrogel Biomaterials Simulating Cells-in-Extracellular Matrix

Identification of Nutritional Ingredients and Medicinal Components of Hawk Tea and Insect Tea Using Widely Targeted Secondary Metabolomics

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