A New Isoflavone Glycoside from the Stems of Tilia taquetii Schneider

Chemical Constituents of Tilia taquetii Leaves and their Inhibition of MMP-1 Expression and Elastase Activities

“…A woody plant Tilia taquetii Schneider (Tiliaceae family) is a Korean endemic which has been used as a folk medicine in local communities against the common cold. In our previous phytochemical study, isoflavone and coumarin derivatives were isolated from the stems of T. taquetii [5]. In a further investigation, we observed that the ethanol extract prepared from the leaves of T. taquetii has inhibition properties on MMP-1 expression and elastase enzyme activities (data not shown).…”

Antineuroinflammatory and Antiproliferative Activities of Constituents from <i>Tilia amurensis</i>

“…Excess production of NO by activated microglia induces neuronal cell death, 3,4) which consequently leads to various neurodegeneration in the CNS. Among isolates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) from the active EtOAc-soluble fraction of T. amurensis, compounds 1-3, 6-7, 13 and 15 were determined to be the active ingredients responsible for anti-neuroinflammatory property of the EtOAc-soluble fraction. Particularly, compounds 2, 3 and 15 (relatively high-yield isolates) are possible to be main contributors to the activity.…”

“…9,10) Our continuing interest in bioactive constituents from T. amurensis led us to further investigate anti-neuroinflammatory metabolites of T. amurensis trunk since its MeOH extract showed anti-neuroinflammatory activity by inhibiting lipopolysaccharide (LPS)-stimulated NO production. A bioassayguided fractionation and chemical investigation of the MeOH extract resulted in the isolation and identification of a new isoflavonoid glycoside, orobol 4′-O-β-D-apiofuranosyl-(1 6)-β-D-glucopyranoside (1) and 16 known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Here, we describe the isolation, structural elucidation, and the anti-neuroinflammatory and antiproliferative activities of the isolated compounds from the T. amurensis trunk.…”

“…The known compounds were identified as pratensein- 11) kelampayoside A (5), 19) osmanthuside H (6), 20) salidroside (7), 21) dihydroconiferin (8), 22) isotachioside (9), 23) tachioside (10), 23) koaburside (11), 24) 2-methoxyhydroquinone (12), 25) scopoletin (13), 26) scopolin (14), 27) fraxin (15), 28) n-butyl β-D-glucopyranoside (16), 29) and adenosine (17) 30) by comparing the spectroscopic data with previously reported values.…”

“…The molecular formula was established as C 26 11) except for the signals of an additional sugar unit, apiose (δ C 109.9, 79.3, 76.9, 73.6, and 64.4). 15) Acid hydrolysis of 1 yielded glucose and apiose detected by co-TLC comparison with authentic samples.…”