A New Kinetic Spectrophotometric Method for Determination of Cefadroxil in Pharmaceutical Formulations Using <i>Lawsonia inermis</i> (Henna) as Natural Reagent

Abstract

A new simple and sensitive kinetic spectrophotometric method has been proposed for the determination of cefadroxil in pure form and pharmaceutical formulations. The proposed method is based on the formation of yellow coloured product (λ max = 410 nm) that resulted after addition of the reagent, which is composed of a mixture of Henna extract, sodium hydroxide and potassium permanganate, to cefadroxil aqueous solution. The experimental conditions have been optimized. Beer's law is obeyed over the concentrations of 100-35 μg/ml, with a linear regression correlation coefficient of 0.996. The proposed method has been successfully applied for the determination of cefadroxil in pharmaceutical dosage forms.

Therapeutic potential of Lawsonia inermis Linn: a comprehensive overview

“…Hassan et al ( 2014 ) published a new simple and precise kinetic spectrophotometric method for the measurement of cefadroxil in both its pure form and pharmaceutical formulations. The proposed method was based on the production of a yellow product (max = 410 nm) from an aqueous solution containing cefadroxil, henna extract, sodium hydroxide, and potassium permanganate.…”

New, Green and Miniaturized Analytical Method for Determination of Cefadroxil Monohydrate in Capsules

“…Many studies are carried out on UV-visible spectrophotometric for the identification and quantification of cefadroxil [16][17][18][19][20][21][22], however, in none of the studies has the technique been presented in microplates, which makes the choice of the method safe to be performed and propitious for the continuity of analyzes that contribute to green analytical chemistry. Ultraviolet and visible spectrophotometryis one of the most frequently employed technique in pharmaceutical analysis [23][24][25][26][27][28][29].…”