A new labdane diterpenoid glycoside and other constituents from Inula nervosa (Asteraceae) and their chemotaxonomic importance

Li, W.; Yang, Yupei; Wu, Juanjiang; Jiang, Sai; Yang, Yong; Guo, Tieding; Wang, Wei; Jian, Yuqing

doi:10.1016/j.bse.2023.104662

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Except for davidigenin and davidioside from B. balsamifera [108], daidzein from D. nervosa [80], orobol 3'-methyl ether from I. japonica [52], pulichalconoids B and C from P. incisa [278], and 5,7,2',3',4'-pentahydroxyisoflavone 4'-O-glucopyranoside from P. undulata [158], chalcones and isoflavonoids (Figures 2 and 3) were minor constituents of the analyzed plant materials and were detected in the plant extracts by TLC or tentatively identified using different variants of liquid chromatography-mass spectrometry (LC-MS).…”

Section: Dihydroquercetinmentioning

confidence: 99%

“…A majority of the isoflavonoids described as metabolites of the Inulae-Inulinae was tentatively identified in the plant material using different variants of the HPLC-MS technique [21,38,40,52,113,121,172]. Daidzein was one of the compounds isolated from the aerial parts of D. nervosa of Chinese origin [80]. The isoflavone was assayed for the anti-inflammatory activity in vitro, by the measurement of the secretion of inflammatory cytokines (TNF-α, IL-6 and IL-1β) in the LPSstimulated RAW 264.7 cells, pretreated with the compound, but was judged as inactive based on its IC50 values [80].…”

Section: Biological Activity Of Isoflavonesmentioning

confidence: 99%

“…Daidzein was one of the compounds isolated from the aerial parts of D. nervosa of Chinese origin [80]. The isoflavone was assayed for the anti-inflammatory activity in vitro, by the measurement of the secretion of inflammatory cytokines (TNF-α, IL-6 and IL-1β) in the LPSstimulated RAW 264.7 cells, pretreated with the compound, but was judged as inactive based on its IC50 values [80]. 5,7,2',3',4'-Pentahydroxyisoflavone 4'-O-glucoside extracted from the whole plant of P. undulata, turned out to be an excellent DPPH radical scavenger in vitro (IC50 = 3.9 μM; quercetin: 7.5 μM) but failed to protect Hepa1c1c7 murine hepatoma cells from the tert-butyl peroxide-induced oxidative damage [158].…”

Section: Biological Activity Of Isoflavonesmentioning

confidence: 99%

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Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

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Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to the plant-environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols, next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from the subtribe (Blumea spp., Dittrichia spp., Inula spp., Pulicaria spp. and others). Recent decades have brought a rapid development of molecular and analytical techniques which resulted in better understanding of the taxonomic relationships within the Inuleae tribe and in a plethora of data concerning the chemical constituents of the Inuleae-Inulinae. The current taxonomical classification has introduced changes in the well-established botanical names and rearranged the genera based on molecular plant genetic studies. The newly created chemical data together with the earlier phytochemical studies may provide some complementary information on biochemical relationships within the subtribe. Moreover, they may at least partly explain pharmacological activities of the plant preparations traditionally used in therapy. The current review aimed to systematize the knowledge on the polyphenols of the Inulae-Inulinae.

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Section: Dihydroquercetinmentioning

confidence: 99%

Section: Biological Activity Of Isoflavonesmentioning

confidence: 99%

Section: Biological Activity Of Isoflavonesmentioning

confidence: 99%

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Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

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“…Previous studies have demonstrated that D. nervosa contains steroids, terpenoids, flavonoids, polysaccharides, and phenolic acids (4), which have a wide range of bioactivities including antiinflammatory, neuroprotective, antioxidant, hepatoprotective, and anticancer properties (5). Some studies have revealed that the root extracts protect HepG2 cells from H 2 O 2 -induced oxidative stress by increasing the expression of Nrf2 and related antioxidant enzymes (6).…”

Section: Introductionmentioning

confidence: 99%

Comparative bioactivity evaluation and metabolic profiling of different parts of Duhaldea nervosa based on GC-MS and LC-MS

Zhao,

Li,

et al. 2023

Front. Nutr.

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Duhaldea nervosa (Wallich ex Candolle) Anderberg has been widely used as medicine and food additive in China for a long history. Its roots, known as Xiaoheiyao, are the mainly used medicinal part, while the other tissues of D. nervosa are ignored as non-medicinal parts despite their high biomass, resulting in a huge waste of resources. To mine and expand the medicinal values of different parts of D. nervosa, metabolic analysis by GC/LC-MS and bioactivity evaluation were performed. Based on the antioxidant activity and correlation analysis, a metabolite-related network was constructed. A total of 45 volatile and 174 non-volatile compounds were identified. Among them, caffeoylquinic acids and derivatives were more abundant in roots and flowers, while coumaroyltartaric acids and derivatives were mainly present in stems and leaves. By multivariate analysis, 13 volatile and 37 non-volatile differential metabolites were found, respectively. In the bioactivity evaluation of different parts, the order of antioxidant capacity was flowers > roots > leaves or stems. The flowers showed the highest FRAP value (354.47 μM TE/g DW) and the lowest IC50 values in the DPPH (0.06 mg/mL) and ABTS (0.19 mg/mL) assay, while higher inhibitory activity against α-glucosidase was exhibited by flowers and leaves. This study first established the similarities and differences of phytochemicals and bioactivities in D. nervosa, providing a scientific basis for developing non-medicinal parts and guiding the clinical application of this medicinal and edible herb.

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A review on ethnobotany, phytochemistry, and pharmacology of the genus Duhaldea DC

Shu,

Li,

Yang

et al. 2024

Front. Pharmacol.

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The botanical drugs of genus Duhaldea DC. have been traditionally utilized in folk medicine for the treatment of a wide array of illnesses, encompassing fractures, bone wounds, carbuncles and poisoning, bronchitis, bruises, giddy with hypertension of qi, and lung deficiency cough. The genus Duhaldea DC. comprises 15 species widespread in Central, East, and Southeast Asia and 7 species (2 endemic) in China. The review aims to provide a systematic overview of ethnopharmacology, phytochemistry, and pharmacology of Duhaldea DC. and to explore the future therapeutic potential and scientific potential of this genus. The data were systematically collected from books and scientific databases such as PubMed, Web of Science, Google Scholar, CNKI, and doctoral and master’s theses. To date, a total of 352 metabolites have been isolated from this genus, and terpenoids, flavonoids, phenylpropanoids, and inositol angelates are the primary contributors to the pharmacological activities of Duhaldea DC. The crude extracts and isolated phytochemical metabolites from this genus have been shown to exhibit various pharmacological activities, including anti-inflammatory, antimicrobial, anti-osteoporotic, anticancer, and antioxidant activities. Despite notable advancements in our understanding of the chemical constituents and pharmacological properties of Duhaldea DC., it is absolutely crucial to conduct additional research into the pharmacology and toxicology of these species to definitively ascertain their safety, efficacy, and quality.

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A new labdane diterpenoid glycoside and other constituents from Inula nervosa (Asteraceae) and their chemotaxonomic importance

Cited by 4 publications

References 25 publications

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Comparative bioactivity evaluation and metabolic profiling of different parts of Duhaldea nervosa based on GC-MS and LC-MS

A review on ethnobotany, phytochemistry, and pharmacology of the genus Duhaldea DC

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