“…, M} Major applications of MIQCQP include quality blending in process networks, separating objects in computational geometry, and portfolio optimization in finance. Specific instantiations of MIQCQP in process networks optimization problems include: pooling problems [5,12,20,28,53,65,66,67,79,93,97,98,100,101,107,137,139], distillation sequences [8,54,58], wastewater treatment and total water systems [9,13,22,29,50,62,71,73,108,109], hybrid energy systems [23,24,49], heat exchanger networks [39,56], reactorseparator-recycle systems [75,76], separation systems [119], data reconciliation [115], batch processes [86], crude oil scheduling [78,80,81,104,103], and natural gas production [82,…”