A new lignan from <i>Zygophyllum aegyptium</i>

Zaki, Ahmed A.; Ali, Zulfiqar; El‐Amier, Yasser A.; Khan, Ikhlas A.

doi:10.1002/mrc.4446

Cited by 5 publications

(7 citation statements)

References 14 publications

(17 reference statements)

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“…H-2''' (δ H 3.83) was recognized by 3 J coupling with C-28 (δ C 169.45). Consequently, from the aforementioned 1D and 2D NMR data and comparison with previously reported data of structurally related compounds, [20,23,28] compound 1 was confirmed as 3-O-[β-D-glucopyranosyl-(1!2)-β-D-glucopyranosyl] quinovic acid-28-)-O-β-D glucopyranosyl ester (Figure 1a) which is isolated for the first time from Family Zygophyllaceae. As a matter of fact, this is the second report of compound 1 in nature in accordance with SciFinder Scholar and Reaxys databases.…”

Section: Resultssupporting

confidence: 60%

“…Plants from the Zygophyllaceae family are widely used in folk medicine as diuretic, anthelmintic, anti‐diabetic, anti‐rheumatic, anti‐asthmatic, and antihypertensive agents . A plethora of studies revealed the presence of flavonoids, phenolic acids, lignans, triterpenoids and sterols in such family …”

Section: Introductionmentioning

confidence: 99%

“…For instance, Zaki and co‐workers applied multiple‐solvents extraction to the aerial parts of Z. aegyptium A. Hosny sp. nov.…”

Section: Introductionmentioning

confidence: 99%

“…[10,12] A plethora of studies revealed the presence of flavonoids, phenolic acids, lignans, triterpenoids and sterols in such family. [10,[17][18][19][20][21][22][23] For instance, Zaki and co-workers [23] applied multiplesolvents extraction to the aerial parts of Z. aegyptium A. Hosny sp. nov.…”

Section: Introductionmentioning

confidence: 99%

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A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

et al. 2020

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Tetraena simplex (L.) Beier & Thulin (syn. Zygophyllum simplex L.) is an annual, succulent plant belonging to family Zygophyllaceae. The plant grows in harsh environmental conditions and it is traditionally used as an analgesic and anti‐inflammatory agent. This study aims to isolate and identify phytochemical constituents of the n‐butanol fraction of its aerial parts that was repeatedly chromatographed on Diaion HP‐20 and silica gel columns to yield a rare triterpenoidal saponin, 3‐O‐[β‐D‐glucopyranosyl‐(1→2)‐β‐D‐glucopyranosyl] quinovic acid‐28‐O‐β‐D‐glucopyranosyl ester (1) along with three other known triterpenoidal compounds namely; 3‐O‐methoxy‐quinovic acid (2), quinovic acid (3), and 3‐O‐β‐D‐glucopyranosyl‐quinovic acid (4). Moreover, quercetin 3‐O‐α‐L‐rhamnoside (5) was isolated from this fraction. Different spectroscopic techniques including one dimensional (1D) and two dimensional (2D) NMR (Nuclear Magnetic Resonance) spectroscopy allowed the unambiguous structure elucidation of the isolated compounds.

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Section: Resultssupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

“…For instance, Zaki and co‐workers applied multiple‐solvents extraction to the aerial parts of Z. aegyptium A. Hosny sp. nov.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

et al. 2020

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“…Wild plants are one of the important components in the ecosystems. Literature indicates that plant secondary metabolism has been reported to possess various biological activities including antioxidant, allelopathic (Abd El-Gawad et al, 2018 a & b;Elshamy et al, 2019), antifungal, antibacterial, antiviral (El-Amier et al, 2014El-Amier and Abo Aisha, 2019), anti-inflammatory (Tohidi et al, 2017), drugs (Zaki et al, 2016a(Zaki et al, & b, 2017(Zaki et al, , 2018 and insecticidal (Castillo et al, 2017) activities. In addition, the wild plant is a good source of food preservation industries, livestock fodder (Zahran and El-Amier, 2013), fibers (Zahran and El-Amier, 2014), fragrance industries, and agro-industrial (Zuin and Ramin, 2018;Alzuaibr et al, 2020) and phytoremediation (El-Amier et al, 2018a & b;El-Alfy et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Euphorbia retusa (Forssk.) A PROMISING SOURCE FOR BIOACTIVE COMPOUNDS IN BIOMEDICAL AND AGRICULTURE APPLICATIONS

El‐Amier¹,

Al-hadithy²,

Fahmy³

et al. 2021

PLANT ARCHIVES

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Euphorbia retusa (family Euphorbiaceae) is an annual plant in the desert of Egypt with a 20 to 60 cm high. The aerial part of the plant containing latex is used in many biological activities. This study aimed to determine the phytochemical constituents, antioxidant, antimicrobial properties and allelopathic activities of aerial parts of E. retusa collected from Wadi Arabah, North Eastern Desert, Egypt. Standard methods were used for the qualitative and quantitative of tannins, saponins, flavonoids, alkaloid, phenolics, steroids, terpenoids, and glycosides. The antioxidant activity was measured based on the reduction of DPPH.Antimicrobial activity was evaluated against pathogenic bacteria, as well as the allelopathic potential against Chenopodium murale was assayed. E. retusa attained the highest values of saponins, tannins, and phenolics compared. In the DPPH test system, the IC50 value of the antioxidant inhibition for E. retusa was 802.74µg mL-1. The data obtained indicated that, the sensitivity of the seedling growth to the extract was higher than the germination of the test species. In addition, the root growth of C. murale was more affected than the shoot system to the inhibitory allelopathic activity induced by E. retusa. At higher concentration (40 g L-1) the germination of the tested seed was highly inhibited by 51.77%, while the shoot and root were reduced by 60.98% and 74.55%, respectively. However, the opposite response was observed at the lower concentration (2.5 g L-1).In conclusion, theextract of E. retusa plant has phytotoxic properties and thus contains phytotoxic substances

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A new anti-inflammatory flavonoid glycoside from tetraena aegyptia

Zaki

Wang

et al. 2019

Natural Product Research

Self Cite

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The chromatographic reinvestigation the methanol extract of Tetraena aegyptia led to the 1), together with two known flavonoids, isorhamnetin (2) and isorhamnetin-3-O-glucoside (3), isolated for the first time from the plant.The new compound was evaluated for the anti-inflammatory activity by using LPS-induce RAW 264.7 cells model. Compound 1 showed significant inhibitory effect on NO release. ELISA assay showed a pronounced effect of 1 on the secretion of cytokines IL-6 and TNF-α, in a dosedependent manner. Consistent results were obtained by qRT-PCR which revealed that compound 1 markedly reduced the mRNA expression of IL-6 and TNF-α. Together these data, we demonstrated the anti-inflammatory activity of compound 1.

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A new lignan from Zygophyllum aegyptium

Cited by 5 publications

References 14 publications

A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

A Rare Triterpenoidal Saponin Isolated and Identified fromTetraena simplex(L.) Beier &Thulin (Syn.Zygophyllum simplexL.)

Euphorbia retusa (Forssk.) A PROMISING SOURCE FOR BIOACTIVE COMPOUNDS IN BIOMEDICAL AND AGRICULTURE APPLICATIONS

A new anti-inflammatory flavonoid glycoside from tetraena aegyptia

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