In this work, we investigate the growth of interface perturbations following the interaction of a shock wave with successive layers of fluids. Using the Discontinuous Galerkin method, we solve the two-dimensional multifluid Euler equations. In our setup, a shock impacts up to four adjacent fluids with perturbed interfaces. At each interface, the incoming shock generates reflected and transmitted shocks and rarefactions, which further interact with the interfaces. By monitoring perturbation growth, we characterize the influence these instabilities have on each other and the fluid mixing as a function of time in different configurations. If the third gas is lighter than the second, the reflected rarefaction at the second interface amplifies the growth at the first interface. If the third gas is heavier, the reflected shock decreases the growth and tends to reverse the Richtmyer-Meshkov instability as the thickness of the second gas is increased. We further investigate the effect of the reflected waves on the dynamics of the small scales and show how a phase difference between the perturbations or an additional fluid layer can enhance growth. This study supports the idea that shocks and rarefactions can be used to control the instability growth.