A New Look at Proliferation

Wilson, George D.

doi:10.1080/02841860152708288

Cited by 13 publications

(17 citation statements)

References 29 publications

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“…It is probable that slowly proliferating female tumors might have greater propensity to recruit cells into rapid cycle in response to treatment than fast proliferating which might have little reserve capacity for further accelerating their cell cycle. 16 Later (mean break, 25 days), RVs were below pretreatment value for all four analyzed subgroups. Starting from about 4-5 weeks, acceleration of cell proliferation was observed again, but only in slowly proliferating female tumors, reaching levels much higher than pretreatment values.…”

Section: Discussionmentioning

confidence: 85%

Gender-Related Differences in Repopulation and Early Tumor Response to Preoperative Radiotherapy in Rectal Cancer Patients

Gasińska

Richter

Darasz

et al. 2011

Journal of Gastrointestinal Surgery

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Section: Discussionmentioning

confidence: 85%

Gender-Related Differences in Repopulation and Early Tumor Response to Preoperative Radiotherapy in Rectal Cancer Patients

Gasińska

Richter

Darasz

et al. 2011

Journal of Gastrointestinal Surgery

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“…H-2K d -Ecad-expressing tumors also showed proliferative, Ki-67-stained cells that were present in a random pattern when compared with the distribution of Ki-67-positive cells seen in control tumors, in which positive cells were limited to the periphery of cell clusters. The random distribution of Ki-67-positive tumor cells has been associated with a considerably poorer survival rate when compared with SCC that displayed an organized, restricted pattern of Ki-67 staining (34). Similarly, in vivo studies in humans have shown that highly infiltrative SCC with a decreased expression of adherens junction proteins has been associated with a poor clinical prognosis (8).…”

Section: Discussionmentioning

confidence: 99%

E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs

et al. 2005

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We studied the link between loss of E-cadherin-mediated adhesion and acquisition of malignant properties in threedimensional, human tissue constructs that mimicked the initial stages of squamous cell cancer progression. Suppression of E-cadherin expression in early-stage, skin-derived tumor cells (HaCaT-II-4) was induced by cytoplasmic sequestration of h h-catenin upon stable expression of a dominant-negative E-cadherin fusion protein (H-2K d -Ecad). In monolayer cultures, expression of H-2K d -Ecad resulted in decreased levels of E-cadherin, redistribution of h h-catenin to the cytoplasm, and complete loss of intercellular adhesion when compared with control II-4 cells. This was accompanied by a 7-fold decrease in h h-catenin-mediated transcription and a 12-fold increase in cell migration. In three-dimensional constructs, E-cadherin-deficient tissues showed disruption of architecture, loss of adherens junctional proteins from cell contacts, and focal tumor cell invasion. Invasion was linked to activation of matrix metalloproteinase (MMP)-mediated degradation of basement membrane in H-2K d -Ecad-expressing tissue constructs that was blocked by MMP inhibition (GM6001). Quantitative reverse transcription-PCR showed a 2.5-fold increase in MMP-2 and an 8-fold increase in MMP-9 in cells expressing the H-2K d -Ecad fusion protein when compared with controls, and gel zymography showed increased MMP protein levels. Following surface transplantation of three-dimensional tissues, suppression of E-cadherin expression greatly accelerated tumorigenesis in vivo by inducing a switch to highgrade carcinomas that resulted in a 5-fold increase in tumor size after 4 weeks. Suppression of E-cadherin expression and loss of its function fundamentally modified squamous cell carcinoma progression by activating a highly invasive, aggressive tumor phenotype, whereas maintenance of E-cadherin prevented invasion in vitro and limited tumor progression in vivo. (Cancer Res 2005; 65(5): 1783-91)

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“…Another property of tumor cells that has recently gained increased recognition is tumor quiescence (13)(14)(15)(16). It is well known that when tumor cells are deprived of the basic nutrients needed to support cell proliferation or are under the stress of tumor growth and anticancer therapy, they can exit the cell cycle and enter prolonged quiescence (G 0 ) (13)(14)(15)(16).…”

Section: Two Components Of Cell Proliferation: Proliferation Rate Andmentioning

confidence: 99%

“…It is well known that when tumor cells are deprived of the basic nutrients needed to support cell proliferation or are under the stress of tumor growth and anticancer therapy, they can exit the cell cycle and enter prolonged quiescence (G 0 ) (13)(14)(15)(16). All solid tumors, even those as small as 2-5 mm, can contain cancer cells that are proliferating and cancer cells that are quiescent.…”

Section: Two Components Of Cell Proliferation: Proliferation Rate Andmentioning

confidence: 99%

Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment

2016

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The development of molecular therapies for cancer treatment has created a need to image biochemical and molecular processes to appropriately select tumors that express the drug target, thereby predicting a positive response to therapy. Biomarker-driven molecular imaging is complementary to pathologic analysis and offers a more direct measure of drug efficacy and treatment response, potentially providing early insight into therapeutic futility and allowing response-adapted treatment strategies. Imaging also allows a unique means of assessing the heterogeneity of both intra-and intertumoral targets as well as a mixed response to therapy; this information is important in the setting of metastatic disease. Here we review the development of novel molecular imaging probes and combinations of probes to guide therapy for two new targets and associated therapeutic agents: cyclin-dependent kinase inhibitors and poly(adenosine diphosphate-ribose) polymerase inhibitors.

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A New Look at Proliferation

Cited by 13 publications

References 29 publications

Gender-Related Differences in Repopulation and Early Tumor Response to Preoperative Radiotherapy in Rectal Cancer Patients

Gender-Related Differences in Repopulation and Early Tumor Response to Preoperative Radiotherapy in Rectal Cancer Patients

E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs

Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment

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