A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides

Abstract

A new lupene triterpenetriol was isolated from the acetone extract of the aerial parts of Salvia sclareoides and characterised as (1β,3β)-lup-20(29)-ene-1,3,30-triol (1). In addition, nepetidin (2), nepeticin (3), lupendiol (4), (1β,11α)-dihydroxy-lup-20(29)-en-3-one (5), ursolic acid (6), sumaresinolic acid (7) and hederagenin (8), were identified in this Salvia sp. To the best of our knowledge, the compounds 2 and 7 are new constituents in Salvia spp. The acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (AChE) and butyrilcholinesterase (BChE), enzymes which play a role in the Alzheimer disease. All extracts inhibited acetylcholinesterase activity at 10 µg/ml, a remarkable activity since the standard drug rivastigmine does not inhibit acetylcholinesterase at the same concentration. Regarding the butyrilcholinesterase, the acetone extract at 1000 µg/ml was able to inhibit completely the enzyme activity and the butanol and ethanol extracts, at this concentration, produced a potent inhibition of BchE.

Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera

“…The diethyl ether extract was inactive. Under the same experimental conditions, rivastigmine, a drug used for medication of Alzheimer's disease patients, showed 95% inhibitory activity at 100 g/mL but did not inhibit the enzyme at the concentration of 10 g/mL (Rauter et al, 2007).…”

ESSENTIAL AND FIXED OIL CHEMICAL COMPOSITIONS OF THE SEEDS FROM THE ENDEMIC SPECIES Salvia Sharifii RECH. F. & ESFAND

“…Abietane, labdane, ictexane, neoclerodane and phenalenone types of diterpenoids [5,6], triterpenoids and sterols [7], phenolic acids, anthocyanins, flavonoids, coumarins and polysaccharides and their derivatives [4] were reported as major constituents of Salvia species. Most Salvia species are rich in essential oils, and various biologically active monoterpenoid/sesquiterpenoid have been reported in them possessing diverse biological activities such as antioxidant [8,9], anti-inflammatory [9,10], analgesic [11], anticonvulsant, anti-ulcerogenic, tranquillizing activities [12] and antibacterial activities [13].…”

Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties

“…The subject of the present study is Salvia sclareoides, a species native to Portugal which exhibits a potent cholinesterase inhibitory activity (Rauter et al, 2007) of relevance to memory dysfunction and Alzheimer's disease. Extracts induced a significant inhibition of acetylcholinesterase, even at the concentration of 10 lg/ml, while the standard drug rivastigmine did not inhibit the enzyme at the same concentration.…”