A new material for hip prosthesis without considerable debris release

Borruto, A.

doi:10.1016/j.medengphy.2010.06.007

Cited by 48 publications

(17 citation statements)

References 23 publications

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“…The growing applications of PEEK‐OPTIMA include load‐bearing surfaces in orthopedic implants. Although historically there has been a dearth of information regarding the performance of PEEK in general, recent articles have shown that particles within the small‐medium‐and large size ranges tested in this investigation are produced from the wear of PEEK implants 74, 75. The clinical relevance of the findings in this investigation (that PEEK‐OPTIMA is generally less inflammatory to macrophages than UHMWPE particles of similar size, shape, and dose) are critically important in the assessment of PEEK‐OPTIMA as a material that aims to improve implant performance.…”

Section: Discussionmentioning

confidence: 93%

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

et al. 2011

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Biologic reactivity to orthopedic implant debris is generally the main determinant of long-term clinical performance where released polymeric particles of Ultra-high molecular weight polyethylene (UHMWPE) remain the most prevalent debris generated from metal-on-polymer bearing total joint arthroplasties. Polymeric alternatives to UHMWPE such as polyetherether-ketone (PEEK) may have increased wear resistance but the bioreactivity of PEEK-OPTIMA particles on peri-implant inflammation remains largely uncharacterized. We evaluated human monocyte/macrophage responses (THP-1s and primary human) when challenged by PEEK-OPTIMA, UHMWPE, and X-UHMWPE particles of three particle sizes (0.7 um, 2 um, and 10 um) at a dose of 20 particles-per-cell at 24- and 48-h time points. Macrophage responses were measured using cytotoxicity assays, viability assays, proliferation assays and cytokine analysis (IL-1b, IL-6, IL-8, MCP-1, and TNF-α). In general, there were no significant differences between PEEK-OPTIMA, UHMWPE, and X-UHMWPE particles on macrophage viability or proliferation. However, macrophages demonstrated greater cytotoxicity responses to UHMWPE and X-UHMWPE than to PEEK-OPTIMA at 24 and 48 h, where 0.7 μm-UHMWPE particles produced the highest amount of cytotoxicity. Particles of X-UHMWPE more than PEEK-OPTIMA and UHMWPE induced IL-1β, IL-6, MCP-1, and TNF-α at 24 h, p < 0.05 (no significant differences at 48 h). On average, cytokine production was more adversely affected by larger 10 μm particles than by 0.7 and 2 μm sized particles. While limitations of in vitro analysis apply to this study, PEEK-OPTIMA particles were more biocompatible than UHMWPE particles, in that they induced less inflammatory cytokine responses and thus, in part, demonstrates that PEEK-OPTIMA implant debris does not represent an increased inflammatory risk over that of UHMWPE.

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Section: Discussionmentioning

confidence: 93%

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

et al. 2011

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“…It should be noted that in the hip joint, the sliding speed is generally between 0 and about 50 mm/s. 24 Wear tests were carried out during 15000 sliding cycles, which corresponds to a total sliding distance of 450 m. The M30NW pin was fixed to the sample holder under a normal load of 20 N. 25 The contact pressure was equal to 60 MPa. 7 From the load transducer of the tribometer, the tangential forces were recorded during the wear tests and the coefficient of friction was, then, calculated.…”

Section: Tribological Testmentioning

confidence: 99%

Tribological properties of High Density Polyethylene based composite: The effect of mollusc shell particles under dry condition

Sidia

Bensalah

2020

Journal of Composite Materials

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This article highlights the importance of the addition of Mollusc shell (MS) particles, as bio-filler, on the tribological behavior of high-density polyethylene (HDPE) matrix. The elaborated biocomposites are intended to be used as an orthopedic replacement biomaterial. Different mass content of MS (0, 5, 10, 15 and 20 wt. %) have been added to the HDPE matrix. FTIR analysis, crystallinity rate and Rockwell hardness of different bio-composites were performed. A reciprocating pin-on-disc tribometer was used to fulfil dry wear tests. FTIR analysis showed that the presence of MS particles improved the crystallinity of the HDPE phase. Adding to that, it was found that MS improved the hardness, friction coefficient and wear resistance of the HDPE polymer. In fact, by adding 5 wt. % of MS to the HDPE, good tribological properties were achieved. Scanning Electron Microscopy (SEM) was performed to investigate the wear morphology of biocomposites under dry condition. SEM images showed that the morphology of the worn surfaces had been improved by the addition of MS to the polymer. Finally, a wear scenario was proposed.

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“…Hip fractures, the leading morbidity resulting from falls, constitute a major and growing socioeconomic problem in health care [27,28]. Since PEEK composites studied in this work are employed for hip replacements [9,25], the impact energy generated in a fall has been used as the reference level.…”

Section: Hip and Skull Fracture Energymentioning

confidence: 99%

“…This enables a reduction in the computational time required for the simulations. A constant friction coefficient value μ=0.27 [27,48] has been used to define the contact projectile/plate. The potential dependence of the friction coefficient on the temperature and the sliding velocity is not taken into account.…”

Section: Numerical Modelmentioning

confidence: 99%

Investigation of mechanical impact behavior of short carbon-fiber-reinforced PEEK composites

Garcia‐Gonzalez

Rodríguez-Millán

Rusinek³

et al. 2015

Composite Structures

114

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Investigation of mechanical impact behavior of short carbon-fiber-reinforced PEEK composites, Composite Structures (2015), doi: http://dx.Abstract. This paper describes the results of an experimental and numerical investigation of the impact behavior of short carbon fiber reinforced polyether-ether-ketone (SCFR PEEK) composites. The biocompatibility of PEEK and its short fiber composites, their rapid processing by injection molding and suitability for modern imaging have supported technological advances in prosthetic implants used in orthopedic medicine. Surgical implants, including hip and cranial implants, can experience clinically significant impact loading during medical installation and useful life. While the incorporation of short fibers in a thermoplastic matrix can produce significant improvements in stiffness and strength, it can also cause a marked reduction in ductility, making study of their energy absorption capability essential. In this work, the mechanical impact behavior of PEEK composites reinforced with polyacrylonitrile (PAN) short carbon fibers 30 % in weight is compared with unfilled PEEK. The perforation tests conducted covered an impact kinetic energy range from 21 J to 131 J, equivalent to the range observed in a fall, the leading cause of hip fractures. Energy absorption capability, damage extension and failure mechanism have been quantified and reported. A numerical modeling that includes homogenization of elastic material and 1 anisotropic damage is presented and validated with experimental data. At all impact energies, SCFR PEEK composites showed a brittle failure and their absorption energy capability decreases drastically in comparison with unfilled PEEK.

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A new material for hip prosthesis without considerable debris release

Cited by 48 publications

References 23 publications

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

Tribological properties of High Density Polyethylene based composite: The effect of mollusc shell particles under dry condition

Investigation of mechanical impact behavior of short carbon-fiber-reinforced PEEK composites

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A new material for hip prosthesis without considerable debris release

Cited by 48 publications

References 23 publications

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

Tribological properties of High Density Polyethylene based composite: The effect of mollusc shell particles under dry condition

Investigation of mechanical impact behavior of short carbon-fiber-reinforced PEEK composites

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Product

Resources

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Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

Macrophage reactivity to different polymers demonstrates particle size‐ and material‐specific reactivity: PEEK‐OPTIMA^®particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges