A New Method for Calculating the Distribution of Radioactivity in Man Measured With A Whole-body Counter

Novario, Raffaele; Conte, L.

doi:10.1097/00004032-199005000-00005

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NCRP Report 83 says that very few studies concerned with the verification of dose calculations using human subjects have been published. The information on cumulated activities has been estimated from only a few direct measurements with positron emission tomography (PET) (Mejia et al 1991, Jones et al 1982, a whole-body counter (Novario and Conte 1990) and LiF TLDs (thermoluminescent dosimeters) (Poston 1976). Furthermore most data from those direct measurements relate to specific organs necessary for nuclear medicine treatment and/or those which accumulate high activity, and the cumulated activities are therefore very scarce for other source organs in humans.…”

Section: Introductionmentioning

confidence: 99%

Estimation of organ cumulated activities and absorbed doses on intakes of several labelled radiopharmaceuticals from external measurement with thermoluminescent dosimeters

et al. 1998

View full text Add to dashboard Cite

We have developed a method for obtaining the cumulated activities in organs from radionuclides, which are injected into the patient in nuclear medicine procedures, by external exposure measurement with thermoluminescent dosimeters (TLDs) which are attached to the patient's body surface close to source organs to obtain information on body-surface doses. As the surface dose is connected to the cumulated activities in source organs through radiation transmission in the human body which can be estimated with the aid of a mathematical phantom, the organ cumulated activities can be obtained by the inverse transform method. The accuracy of this method was investigated by using a water phantom in which several gamma-ray volume sources of known activity were placed to simulate source organs. We then estimated by external measurements the organ cumulated activities and absorbed doses in subjects to whom the radiopharmaceuticals 11C-labelled Doxepin, 11C-labelled YM09151-2 and 11C-labelled Benzotropin were administered in clinical nuclear medicine procedures. The cumulated activities in the brain obtained with TLDs for Doxepin and YM09151-2 are 63.6 +/- 6.2 and 32.1 +/- 12.0 kBq h MBq-1 respectively, which are compared with the respective values of 33.3 +/- 9.9 and 23.9 +/- 6.2 kBq h MBq-1 with direct PET (positron emission tomography) measurements. The agreement between the two methods is within a factor of two. The effective doses of Doxepin, YM09151-2 and Benzotropin are determined as 6.92 x 10(-3), 7.08 x 10(-3) and 7.65 x 10(-3) mSv MBq-1 respectively with the TLD method. This method has great advantages, in that cumulated activities in several organs can be obtained easily with a single procedure, and the measurements of body surface doses are performed simultaneously with the nuclear medicine procedure, as TLDs are too small to interfere with other medical measurements.

show abstract

Section: Introductionmentioning

confidence: 99%